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Open AccessArticle

Actinofuranones D-I from a Lichen-Associated Actinomycetes, Streptomyces gramineus, and Their Anti-Inflammatory Effects

1
Institute of Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110819, China
2
Yunnan Institute of Microbiology, School of Life Science, Yunnan University, Kunming 650091, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(9), 2393; https://doi.org/10.3390/molecules23092393
Received: 31 August 2018 / Revised: 14 September 2018 / Accepted: 17 September 2018 / Published: 18 September 2018
Six new metabolites, actinofuranones D-I (compounds 16), were isolated together with three known compounds—JBIR-108 (7), E-975 (8), and E-492 (9)—from a fermentation broth of Streptomyces gramineus derived from the lichen Leptogium trichophorum. The structures of the new compounds 16 were established using comprehensive NMR spectroscopic data analysis, as well as UV, IR, and MS data. The anti-inflammatory activity of these isolated compounds were evaluated by examining their ability to inhibit nitric oxide (NO) production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 4, 5, 8, and 9 attenuated the production of NO due to the suppression of the expression of nitric oxide synthase (iNOS) in LPS-induced RAW 264.7 cells. Moreover, 4, 5, 8, and 9 also inhibited LPS-induced release of proinflammatory cytokines interleukin-6 (IL-6) and tumor necrosis factor α (TNF-α). View Full-Text
Keywords: lichen-associated actinomycetes; actinofuranones; RAW 264.7 macrophages; anti-inflammatory lichen-associated actinomycetes; actinofuranones; RAW 264.7 macrophages; anti-inflammatory
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MDPI and ACS Style

Ma, J.; Cao, B.; Liu, C.; Guan, P.; Mu, Y.; Jiang, Y.; Han, L.; Huang, X. Actinofuranones D-I from a Lichen-Associated Actinomycetes, Streptomyces gramineus, and Their Anti-Inflammatory Effects. Molecules 2018, 23, 2393.

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