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Article

Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012

1
Key Laboratory of Tropical Marine Bio-resources and Ecology/Guangdong Key Laboratory of Marine Materia Medica/Research Center for Marine Microbes, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(9), 2379; https://doi.org/10.3390/molecules23092379
Received: 23 August 2018 / Revised: 4 September 2018 / Accepted: 11 September 2018 / Published: 18 September 2018
Two new alkaloids, fumigatosides E (1) and F (2), and a new natural product, 3, 7-diketo-cephalosporin P1 (6) along with five known compounds (35, 7, 8) were isolated from deep-sea derived fungal Aspergillus fumigatus SCSIO 41012. Their structures were determined by extensive spectroscopic data analysis, including 1D, 2D nuclear magnetic resonance (NMR) and mass spectrometry (MS), and comparison between the calculated and experimental electronic circular dichroism (ECD) spectra. In addition, all compounds were tested for antibacterial and antifungal inhibitory activities. Compound 1 showed significant antifungal activity against Fusarium oxysporum f. sp. momordicae with MIC at 1.56 µg/mL. Compound 4 exhibited significant higher activity against S. aureus (16,339 and 29,213) with MIC values of 1.56 and 0.78 µg/mL, respectively, and compound 2 exhibited significant activity against A. baumanii ATCC 19606 with a MIC value of 6.25 µg/mL. View Full-Text
Keywords: deep sea-derived fungus; Aspergillus fumigatus SCSIO 41012; indole alkaloids; steroids; antibacterial activity; antifungal activity deep sea-derived fungus; Aspergillus fumigatus SCSIO 41012; indole alkaloids; steroids; antibacterial activity; antifungal activity
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MDPI and ACS Style

Limbadri, S.; Luo, X.; Lin, X.; Liao, S.; Wang, J.; Zhou, X.; Yang, B.; Liu, Y. Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012. Molecules 2018, 23, 2379. https://doi.org/10.3390/molecules23092379

AMA Style

Limbadri S, Luo X, Lin X, Liao S, Wang J, Zhou X, Yang B, Liu Y. Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012. Molecules. 2018; 23(9):2379. https://doi.org/10.3390/molecules23092379

Chicago/Turabian Style

Limbadri, Salendra, Xiaowei Luo, Xiuping Lin, Shengrong Liao, Junfeng Wang, Xuefeng Zhou, Bin Yang, and Yonghong Liu. 2018. "Bioactive Novel Indole Alkaloids and Steroids from Deep Sea-Derived Fungus Aspergillus fumigatus SCSIO 41012" Molecules 23, no. 9: 2379. https://doi.org/10.3390/molecules23092379

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