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Molecules 2018, 23(9), 2336; https://doi.org/10.3390/molecules23092336

Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions

Post Graduate Program in Health and Development in the Central-West Region of Brazil, Federal University of Mato Grosso do Sul-UFMS, Campo Grande 79070-900, MS, Brazil
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Received: 17 August 2018 / Revised: 3 September 2018 / Accepted: 4 September 2018 / Published: 13 September 2018
(This article belongs to the Special Issue Medicinal Plants and Diabetes)
Full-Text   |   PDF [309 KB, uploaded 13 September 2018]

Abstract

Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects. Though there are different varieties of guavira, the principal Brazilian Cerrado guaviras demonstrated hypoglycemic, anti-inflammatory, and hypocholesterolemic actions. There is also a potential antiplatelet agent in C. xanthocarpa, while C. adamantium displayed hypocholesterolemic actions in animal models and human clinical trials. On the other hand, even with a lack of studies related to C. pubescens, it demonstrated anti-inflammatory effects and an antioxidant capacity in in vitro studies. Despite the fact that most of the studies were not performed to evaluate pathological conditions specific to obese animal models or obese subjects, guavira demonstrated effects in metabolic disorders that are commonly related to the obesity context, such as cardiovascular disturbances and hyperglycemia status. This suggests that guavira is a potential therapeutic approach to obesity-induced metabolic syndrome. View Full-Text
Keywords: Campomanesia species; medicinal plants; Brazilian Cerrado; obesity-induced metabolic syndrome Campomanesia species; medicinal plants; Brazilian Cerrado; obesity-induced metabolic syndrome
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Cardozo, C.M.L.; Inada, A.C.; Marcelino, G.; Figueiredo, P.S.; Arakaki, D.G.; Hiane, P.A.; Cardoso, C.A.L.; Guimarães, R.C.A.; Freitas, K.C. Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions. Molecules 2018, 23, 2336.

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