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Suppressive Effects of EGCG on Cervical Cancer

Tea Research Institute, Zhejiang University, # 866 Yuhangtang Road, Hangzhou 310058, China
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Academic Editor: Helieh S. Oz
Molecules 2018, 23(9), 2334; https://doi.org/10.3390/molecules23092334
Received: 9 August 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 12 September 2018
(This article belongs to the Special Issue EGCG, Green Tea and Polyphenols)
Cervical cancer is the fourth most common gynecological cancer worldwide. Although prophylactic vaccination presents the most effective method for cervical cancer prevention, chemotherapy is still the primary invasive intervention. It is urgent to exploit low-toxic natural anticancer drugs on account of high cytotoxicity and side-effects of conventional agents. As a natural product, (-)-epigallocatechingallate (EGCG) has abilities in anti-proliferation, anti-metastasis and pro-apoptosis of cervical cancer cells. Moreover, EGCG also has pharmaceutical synergistic effects with conventional agents such as cisplatin (CDDP) and bleomycin (BLM). The underlying mechanisms of EGCG suppressive effects on cervical cancer are reviewed in this article. Further research directions and ambiguous results are also discussed. View Full-Text
Keywords: Camellia sinensis; EGCG; cervical cancer; human papillomavirus (HPV); anticancer Camellia sinensis; EGCG; cervical cancer; human papillomavirus (HPV); anticancer
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MDPI and ACS Style

Wang, Y.-Q.; Lu, J.-L.; Liang, Y.-R.; Li, Q.-S. Suppressive Effects of EGCG on Cervical Cancer. Molecules 2018, 23, 2334. https://doi.org/10.3390/molecules23092334

AMA Style

Wang Y-Q, Lu J-L, Liang Y-R, Li Q-S. Suppressive Effects of EGCG on Cervical Cancer. Molecules. 2018; 23(9):2334. https://doi.org/10.3390/molecules23092334

Chicago/Turabian Style

Wang, Ying-Qi, Jian-Liang Lu, Yue-Rong Liang, and Qing-Sheng Li. 2018. "Suppressive Effects of EGCG on Cervical Cancer" Molecules 23, no. 9: 2334. https://doi.org/10.3390/molecules23092334

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