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2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo

by Mengnan Zeng 1,2,†, Meng Li 1,2,†, Miao Li 1,2, Beibei Zhang 1,2, Benke Li 1,2, Li Zhang 1,2, Weisheng Feng 1,2 and Xiaoke Zheng 1,2,*
1
Department of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
2
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment & Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work and should be considered co-first authors.
Molecules 2018, 23(9), 2293; https://doi.org/10.3390/molecules23092293
Received: 30 July 2018 / Revised: 28 August 2018 / Accepted: 5 September 2018 / Published: 7 September 2018
The aim of this study was to investigate the estrogen-like effects of 2-phenylacetamide (PA), which is the main compound isolated from the seeds of Lepidium apetalum Willd (LA). Results showed that LA and PA could promote the proliferation of MCF-7 cells. The mouse uterine weight test showed that, LA and PA could increase the uterus index of immature female mice, and the levels of luteinizing hormone (LH) and estrogen (E2). LA could increase the expression of ERα and ERβ, while PA could increase the expression of ERα, ERβ and GPR30 in the uterus and MCF-7 cells. In addition, co-incubation of the estrogen receptor blocker with LA or PA abolished the inductive effect of the proliferation. PA has estrogenic activities and was the material basis of LA that played the estrogenic effect. LA and PA might be used for the treatment of perimenopause syndrome in a novel application. View Full-Text
Keywords: Lepidium apetalum Willd; 2-phenylacetamide; estrogen-like effects; ERα; ERβ; GPR30 Lepidium apetalum Willd; 2-phenylacetamide; estrogen-like effects; ERα; ERβ; GPR30
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MDPI and ACS Style

Zeng, M.; Li, M.; Li, M.; Zhang, B.; Li, B.; Zhang, L.; Feng, W.; Zheng, X. 2-Phenylacetamide Isolated from the Seeds of Lepidium apetalum and Its Estrogen-Like Effects In Vitro and In Vivo. Molecules 2018, 23, 2293.

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