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Molecules 2018, 23(9), 2205; https://doi.org/10.3390/molecules23092205

Application of Dendrimers for the Treatment of Infectious Diseases

Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa
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Received: 14 May 2018 / Revised: 14 June 2018 / Accepted: 15 June 2018 / Published: 31 August 2018
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Abstract

Dendrimers are drug delivery systems that are characterized by a three-dimensional, star-shaped, branched macromolecular network. They possess ideal properties such as low polydispersity index, biocompatibility and good water solubility. They are made up of the interior and the exterior layers. The exterior layer consists of functional groups that are useful for conjugation of drugs and targeting moieties. The interior layer exhibits improved drug encapsulation efficiency, reduced drug toxicity, and controlled release mechanisms. These unique properties make them useful for drug delivery. Dendrimers have attracted considerable attention as drug delivery system for the treatment of infectious diseases. The treatment of infectious diseases is hampered severely by drug resistance. Several properties of dendrimers such as their ability to overcome drug resistance, toxicity and control the release mechanism of the encapsulated drugs make them ideal systems for the treatment of infectious disease. The aim of this review is to discuss the potentials of dendrimers for the treatment of viral and parasitic infections. View Full-Text
Keywords: dendrimers; polymers; antivirals; parasites; drug delivery dendrimers; polymers; antivirals; parasites; drug delivery
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Mhlwatika, Z.; Aderibigbe, B.A. Application of Dendrimers for the Treatment of Infectious Diseases. Molecules 2018, 23, 2205.

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