Enhancing the Delivery of Chemotherapeutics: Role of Biodegradable Polymeric Nanoparticles
The Department of Chemistry & Biochemistry, The University of Texas at El Paso, El Paso, TX 79968, USA
Environment Science & Engineering Department, The University of Texas at El Paso, El Paso, TX 79968, USA
Author to whom correspondence should be addressed.
Molecules 2018, 23(9), 2157; https://doi.org/10.3390/molecules23092157
Received: 30 July 2018 / Revised: 12 August 2018 / Accepted: 15 August 2018 / Published: 27 August 2018
(This article belongs to the Special Issue Directed Drug Design and Molecular Therapy)
While pharmaceutical drugs have revolutionized human life, there are several features that limit their full potential. This review draws attention to some of the obstacles currently facing the use of chemotherapeutic drugs including low solubility, poor bioavailability and high drug dose. Overcoming these issues will further enhance the applicability and potential of current drugs. An emerging technology that is geared towards improving overall therapeutic efficiency resides in drug delivery systems including the use of polymeric nanoparticles which have found widespread use in cancer therapeutics. These polymeric nanoparticles can provide targeted drug delivery, increase the circulation time in the body, reduce the therapeutic indices with minimal side-effects, and accumulate in cells without activating the mononuclear phagocyte system (MPS). Given the inroads made in the field of nanodelivery systems for pharmaceutical applications, it is of interest to review and emphasize the importance of Polymeric nanocarrier system for drug delivery in chemotherapy.