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Molecules 2018, 23(8), 1966; https://doi.org/10.3390/molecules23081966

16-Hydroxycleroda-3,13-dien-15,16-olide and N-Methyl-Actinodaphine Potentiate Tamoxifen-Induced Cell Death in Breast Cancer

1
Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam
2
Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Hualien 97401, Taiwan
*
Author to whom correspondence should be addressed.
Received: 15 June 2018 / Revised: 21 July 2018 / Accepted: 1 August 2018 / Published: 6 August 2018
(This article belongs to the Collection Herbal Medicine Research)
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Abstract

In this study, we investigated whether 16-hydroxycleroda-3,13-dien-15,16-olide (HCD) and N-methyl-actinodaphine (MA) could sensitize breast cancer cells to Tamoxifen (TMX) treatment. MA or HCD alone or in combination with TMX dose-dependently inhibited MCF-7 and MDA-MB-231 cell growth, with a more potent inhibition on MDA-MB 231 cells. Furthermore, this novel combination significantly induced S and G2/M cell cycle phase in MDA-MB 231 than MCF-7 cells. Further determination of the apoptotic induction showed that MA or HCD and TMX combination inhibited MDA-MB-231 and MCF-7 cancer cells by upregulating Bax and by downregulating Bcl-2 mRNA and protein expression without altering Caspase-8 and Caspase-12 expression. These results suggest that MA or HCD pretreatment may potentiate the anti-tumor effect of tamoxifen on breast cancer. View Full-Text
Keywords: HCD; MA; TMX; apoptosis; Bcl2; Bax HCD; MA; TMX; apoptosis; Bcl2; Bax
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
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Velmurugan, B.K.; Wang, P.-C.; Weng, C.-F. 16-Hydroxycleroda-3,13-dien-15,16-olide and N-Methyl-Actinodaphine Potentiate Tamoxifen-Induced Cell Death in Breast Cancer. Molecules 2018, 23, 1966.

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