Next Article in Journal
Neuroprotective Effects of Mitochondria-Targeted Plastoquinone in a Rat Model of Neonatal Hypoxic–Ischemic Brain Injury
Next Article in Special Issue
Immobilizing Polyether Imidazole Ionic Liquids on ZSM-5 Zeolite for the Catalytic Synthesis of Propylene Carbonate from Carbon Dioxide
Previous Article in Journal
High-Throughput Analysis of Selected Urinary Hydroxy Polycyclic Aromatic Hydrocarbons by an Innovative Automated Solid-Phase Microextraction
Previous Article in Special Issue
Effect of Hydrophobic Polypeptide Length on Performances of Thermo-Sensitive Hydrogels
Article Menu
Issue 8 (August) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(8), 1870;

Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value

Shandong Provincial Key Laboratory of Oilfield Chemistry, School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, China
Department of Chemistry, Capital Normal University, 105 West 3rd Ring North Rd, Beijing 100048, China
Author to whom correspondence should be addressed.
Academic Editors: Jianxun Ding, Yang Li and Mingqiang Li
Received: 25 June 2018 / Revised: 12 July 2018 / Accepted: 15 July 2018 / Published: 27 July 2018
(This article belongs to the Special Issue Smart and Functional Polymers)
Full-Text   |   PDF [1911 KB, uploaded 27 July 2018]   |  


Novel pH responsive copolymers with tertiary amine groups were prepared by free radical polymerization with 2-(dialkylamino)ethyl methacrylate monomers. These polymers were pH sensitive with the ability to be responsively fine-tuned in aqueous solution, which was proven through titration, transmittance measurements, and proton nuclear magnetic resonance spectroscopy. The polymers were soluble in water at low pH values, induced by electrostatic repulsion between amine groups, and aggregated above their pKa value due to the hydrophobic effect of the alkyls. The pH responsive values were precisely tuned from 7.4 to 4.8 by increasing the hydrophobic monomer ratio. Our work provides a novel approach for the development of ultrasensitive pH-responsive polymers for application in biomedical materials. View Full-Text
Keywords: fine-tuning; pH responsive; poly(methacrylamide)s; phase transition fine-tuning; pH responsive; poly(methacrylamide)s; phase transition

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Fan, H.; Li, P.; Li, W.; Li, H.; Huang, X. Ultrasensitive (Co)polymers Based on Poly(methacrylamide) Structure with Fining-Tunable pH Responsive Value. Molecules 2018, 23, 1870.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top