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Molecules 2018, 23(7), 1805;

Physicochemical Properties of Lutein-Loaded Microcapsules and Their Uptake via Caco-2 Monolayers

Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling 712100, China
Authors to whom correspondence should be addressed.
Received: 5 July 2018 / Revised: 14 July 2018 / Accepted: 16 July 2018 / Published: 20 July 2018
(This article belongs to the Special Issue Natural Products Used as Foods and Food Ingredients)
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Lutein is one of the most important carotenoids that can be utilized in foods as a natural pigment and nutraceutical ingredient to improve eye health. However, its utilization is limited due to its poor solubility. Chemically, the highly unsaturated structure of lutein makes it extremely susceptible to light, oxygen, heat, and pro-oxidants and therefore easily oxidized, decomposed or dissociated. In this study, we aimed to imbed natural lutein to improve its storage stability and enhance its water dispersibility. As two commonly studied water-soluble and water-insoluble food-grade surfactants, sodium caseinate (NaCas) and lecithin were chosen as the wall materials, and lutein-loaded lecithin microcapsules and NaCas microcapsules were prepared, the results revealed the lutein-loaded NaCas microcapsules not only exhibited better dispersibility and stability than those of lutein-loaded lecithin microcapsules, but also were more stable when stored at 4 °C, 25 °C, 37 °C. Moreover, the lutein-loaded NaCas microcapsules were more easily absorbed by the intestinal Caco-2 cells than natural lutein. Considering the dispersibility, stability and cell absorption effect, the NaCas-based microparticle is a potential carrier for lutein. View Full-Text
Keywords: lutein; microcapsules; dispersibility; storage stability; cell absorption lutein; microcapsules; dispersibility; storage stability; cell absorption

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Zhao, T.; Liu, F.; Duan, X.; Xiao, C.; Liu, X. Physicochemical Properties of Lutein-Loaded Microcapsules and Their Uptake via Caco-2 Monolayers. Molecules 2018, 23, 1805.

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