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Molecules 2018, 23(7), 1802;

Conversion of Fructose to HMF in a Continuous Fixed Bed Reactor with Outstanding Selectivity

Thuenen Institute of Agricultural Technology, Bundesallee 47, 38116 Braunschweig, Germany
Author to whom correspondence should be addressed.
Academic Editors: Michela Signoretto and Federica Menegazzo
Received: 28 June 2018 / Revised: 12 July 2018 / Accepted: 18 July 2018 / Published: 20 July 2018
(This article belongs to the Special Issue Platform Chemical: Hydroxymethylfurfural (HMF))
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5-Hydroxymethylfurfural (HMF) is a very promising component for bio-based plastics. Efficient synthesis of HMF from biomass is still challenging because of fast degradation of HMF to by-products under formation conditions. Therefore, different studies, conducted mainly in monophasic and biphasic batch systems with and without water addition have been published and are still under investigation. However, to produce HMF at a large scale, a continuous process is preferable. Until now, only a few studies have been published in this context. In this work, it is shown that fluorous alcohol hexafluoroisopropanol (HFIP) can act as superior reaction solvent for HMF synthesis from fructose in a fixed bed reactor. Very high yields of 76% HMF can be achieved in this system under optimized conditions, whilst the catalyst is very stable over several days. Such high yields are only described elsewhere with high boiling reaction solvents like dimethylsulfoxide (DMSO), whereas HFIP with a boiling point of 58 °C is very easy to separate from HMF. View Full-Text
Keywords: HMF; continuous fixed bed reactor; heterogeneous catalysis; HFIP; fructose HMF; continuous fixed bed reactor; heterogeneous catalysis; HFIP; fructose

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Weingart, E.; Tschirner, S.; Teevs, L.; Prüße, U. Conversion of Fructose to HMF in a Continuous Fixed Bed Reactor with Outstanding Selectivity. Molecules 2018, 23, 1802.

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