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Review

Ionic Liquid Solutions as a Green Tool for the Extraction and Isolation of Natural Products

by
Jiao Xiao
,
Gang Chen
and
Ning Li
*
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, China
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(7), 1765; https://doi.org/10.3390/molecules23071765
Submission received: 11 June 2018 / Revised: 13 July 2018 / Accepted: 14 July 2018 / Published: 18 July 2018
(This article belongs to the Special Issue Ionic Liquids for Chemical and Biochemical Applications)
Versions Notes

Abstract

:
In the past few years, the application of ionic liquids (ILs) had attracted more attention of the researchers. Many studies focused on extracting active components from traditional herbals using ILs as alternative solvents so as to address the issue caused by the traditional methods for extraction of natural products (NPs) with organic chemical reagents. Through the summary of reported research work, an overview was presented for the application of ILs or IL-based materials in the extraction of NPs, including flavonoids, alkaloids, terpenoids, phenylpropanoids and so on. Here, we mainly describe the application of ILs to rich the extraction of critical bioactive constituents that were reported possessing multiple therapeutic effects or pharmacological activities, from medicinal plants. This review could shed some light on the wide use of ILs in the field of natural products chemistry to further reduce the environmental damage caused by large quantity of organic chemical reagents.

1. Introduction

Natural products (NPs) were the most important resource of leading compounds for drug discovery [1,2,3]. Indeed, approximately 40% of drugs available for clinical use were derived from natural chemical structures [4,5]. For example, the most famous antimalarial drug artemisinin, which was first isolated from Artemisia annua L., and the finding of it had been awarded the Nobel Prize in 2015 [6,7]. The reason for this success in drug discovery can probably be explained by the high chemical diversity of NPs across many species of the original plants [8]. While, discovery of the chemical diversity demands special methods to extract and isolate target products from different herbals [9]. Usually, organic solvent extraction was the optimal choice to obtain NPs. However, there were two major barriers for the discovery of NPs now. One was the low abundance of some active NPs in herbals [2,10]. In order to get enough amount of target products, large volumes of organic solvents were employed in the extraction and purification processes. The other barrier was the high repetition rate in the discovery of NPs across different species [11].
ILs were a group of organic salts, in general, composed of organic cation (e.g., imidazolium, pyrrolidinium, pyridinium tetraalkyl ammonium, tetraalkyl phosphonium) and inorganic or organic anion (e.g., tetrafluoroborate, hexafluorophosphate and bromide) and presented in the form of liquid when below 100 °C [12,13]. Now, ILs had been widely applied due to their unique and structure-dependent properties [14], such as the negligible vapor pressure [15], low nucleophilicity [16], miscibility with water or organic solvents, and good extractability for the organic compounds and metal ions. With these characteristics, ILs were more environmentally benign solvents comparing to the traditional volatile organic solvents used for extraction [17]. Therefore, many researchers had utilized IL-based technologies to extract and purify bioactive components from herbal medicines. Thus, this review would highlight the application of ILs in the extraction and purification of special bioactive NPs.

2. Extraction of Active Component Groups from Plants by ILs

Active component groups, such as flavonoids fraction, polysaccharides fraction and alkaloids fraction, had been reported as the active material basis of the traditional herbals. Herein, we summarized the application of ILs as a green tool for extraction flavonoids and polysaccharides fractions. All the acronyms of ILs described in this paper are listed in Table 1.

2.1. The Flavonoids Fraction

Flavonoids had been found as active ingredients in herbals, fruits, vegetables, tea, red wine and so on. Some of the compounds were well bioavailable after being ingested, and therefore exert diverse biological effects [18]. Here, we presented the reported application of ILs in the extraction of natural flavonoids fraction (Table 2), and described two research cases as follows.
The first case was the extraction of the flavonoids fraction from Broussonetia papyrufera (L.) Vent. It had been reported that flavonoids should be the major active composition of the traditional herbal medicine B. papyrufera (L.) Vent to treat dysentery, hypotension and cancer [19,20]. In the previous work, the flavonoids fraction was extracted by large amounts of volatile organic solvents including ethyl acetate, n-butyl alcohol, methanol, ethanol and so on, leading to inherent environmental concerns [21]. To overcome the major drawbacks of the traditional extraction methods, Wang and co-workers [21] employed [HBth][CH3SO3], a kind of functional IL, to extract the flavonoids fraction from leaves of the plant. As a result, the yield of the flavonoids fraction was doubled comparing with that of the traditional method without ionic liquids.
In the other case, Tan et al. reported [22] that the extraction of the flavonoids fraction from the leaves of Apocynum venetum [22,23,24,25] using the IL [C4mim][N(CN)2] aqueous solution. The extraction conditions of IL concentration, liquid/solid ratio, and ultrasonic time were optimized by RSM (response surface method), with further purification of the flavonoids by ABS (aqueous biphasic system). With the developed methodology, the yield of flavonoids reached 83.5%, increasing 32 folds compared with ultrasound-assisted extraction without ILs [26].

2.2. The Polysaccharides Fraction

Polysaccharides extensively existed in our dietary food, herbal medicines, and marine organism. Especially, many species of marine alga contained large quantities of polysaccharides with anti-tumor, anti-viral, anti-oxidant, anti-infective, and anti-mutagenic activities [41,42]. In Table 3, the application of ILs for extraction of polysaccharides fraction were listed.
Many species of marine alga, especially red and brown
Aloe polysaccharides were the major active constitutes of the Aloe vera L. [43]. Various methods were used for separation and purification of Aloe polysaccharides, such as ethanol precipitation, ion-exchange chromatography [44], and membrane separation [45]. However, Tan et al. [46] employed an IL ([Bmim]BF4) based aqueous two-phase system for the extraction of aloe polysaccharides. This modified method raised the yield of Aloe polysaccharides from 85.20% [44] to 93.12%.

3. Extraction of Single Compounds from Plants by ILs

The classical way of purification for single compounds from the plants started with extraction, and subsequently treated with repeated chromatography, such as macroporous resin, silica gel, Sephadex LH-20 column chromatography and HPLC methods [51]. These processes of purification were a waste of time and money [52]. However, ILs had been proposed to catch NPs [53] with their unique chemical functional groups [15]. Until now, there were 236 compounds characterized by ILs from plants reported in 167 references, including flavonoids (compounds 1–65), alkaloids (compounds 66–129), terpenoids (compounds 130–187), phenylpropanoids (compounds 188–215), quinones (compounds 216–233), and others (compounds 234–236). Their chemical structures are presented in Figures S1–S6.

3.1. Flavonoids (Compounds 1–65)

Flavonoids were built upon a C6–C3–C6 skeleton, in which the C3 unit usually characterized different types of flavonoids, including flavones, flavonols, isoflavones, chalcones, anthocyanidins and so on (Figure S1) [54]. Moreover, hydroxyl, methoxyl, and glycosyl groups commonly existed in flavonoid structures. All the flavonoids extracted from natural sources by the application of ILs were described in Figure S1 and Table 4. A total of 65 flavonoids were summarized here, including 41 flavones, 13 isoflavones, three flavanones and eight anthocyanidins.
Taking rutin (quercetin-3-O-rutinoside, compound 1) as an example. It had been found in many herbs as the active component, including Abutilon theophrasti [54], Tamarix Chinensis [55], Sophora japonica L. and so on. It could be extracted by different solvent-extraction processes based on its acidity and polarity. For the polarity of rutin, ethanol-water was usually used to extract rutin under reflux [56]. While Ca(OH)2 solution was also employed to enrich acidic rutin [57]. However, the shortcomings of the traditional methods, such as low yield about 8% [56] and time-consuming restricted their further application. Hence, Zhao et al. [58] developed a new method using IL [C4mim]Br based on ultrasonic- and microwave-assisted extraction (UMAE) for extracting rutin from the leaves of A. theophrasti. The yield of rutin obtained by ILs-UMAE method was 5.49 mg/g, increasing 2.01 folds than that of heating reflux extraction with methanol. While, Wang [55] and co-workers used [Bmim]Br as solvent to extract rutin from T. Chinensis, and the yield of rutin was 0.0756%, which was 15.1% higher than that of the ultrasonic extraction with methanol.

3.2. Alkaloids (Compounds 66–129)

Alkaloids were a group of compounds containing one or more carbon rings and basic nitrogen atoms (Figure S2). [92]. According to their biosynthesis pathway and chemical characteristics, alkaloids were divided into phenylalanine-derived, tryptophan-derived, and terpenoid alkaloids, etc. In total 64 alkaloids extracted from natural sources by the application of ILs solutions were described in Figure S2 and Table 5.
Sinomenine (7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methylmorphinan-6-one, 66), is a bioactive alkaloid isolated from the root and stem of Sinomenium acutum [93,94] and Diploclisia affinis [95]. There are two common ways to get sinomenine, one was alkalizing the plant material with Ca(OH)2 and NH3·H2O, then extracted them using benzene or chloroform [95,96], further separated it on macroporous resin. And the other was percolating or refluxing with 75% ethanol-water (v:v) [97,98] for 2 h. Li and co-workers [99] developed magnetic ionic liquids (MILs) ([C2OHmim] FeCl4) based on UAE to extract sinomenine from S. acutum. Compared with reflux extraction by 70% ethanol-water (v:v) and pure water, the yield of sinomenine with MILs increased 2.4 and 2.8 folds, respectively. In addition, ILs also reduced the extraction time course from 4 h to 30 min.
Dong [100] also employed an approach using ILs for extracting five alkaloids (compounds 85–89) from Physochlainae infundibularis. Through investigating four critical factors on the yield of alkaloids, including concentrations of ionic liquid, the solid–liquid ratio, extraction time and temperature, Dong found that 0.05 mol/L [C3tr][PF6] aqueous solution had the highest extraction efficiency at 95.1%. It took less time (55 min as opposed to 80 min) for above ionic liquid aqueous solution compared to the extraction with water [101], to extract those five alkaloids from natural plants.

3.3. Terpenoids (Compounds 130–187)

The terpenoids were a large family of NPs with general formula of (C5H8)n, including monoterpene, sesquiterpene, diterpene, sesterpene, triterpene, and others [116,117] (Figure S3). All the terpenoids extracted from natural sources with ILs were described in Figure S3 and Table 6, which included a total of 58 terpenoids (19 monoterpenoids, nine sesquiterpenoids, 10 iridoids, two diterpenoids and 18 triterpenoids).
Paclitaxel (compound 169), a well-known clinical antitumor drug, was a diterpenoid existing in various Taxus species [118,119,120,121]. Usually, there were two methods for the extraction of paclitaxel from the original plant. One was soaking with 95% ethanol-water for 16 h [122] at room temperature, and the other was refluxing with methanol [123,124]. Both of them required plenty of time for extraction. Therefore, Tan [125] used MILs [C4mim]FeCl3Br along with methanol solution for extracting paclitaxel from Taxus species. By optimizing major factors, such as IL amount, solid-liquid ratio, and ultrasonic time, the yield was improved to 0.224 mg/g, which was twice as much as that produced by traditional reflux extraction with methanol under reflux. Meanwhile, the main advantage of the proposed method versus the conventional one (soaking with 95% ethanol-water) was the considerable reduction of time from 16 h to 30 min.

3.4. Phenylpropanoids (Compounds 188–215)

The general skeleton of phenylpropanoids bore a series of C6–C3 units [141], for instance, coumarins and lignans were two important types of NPs. There were 28 phenylpropanoids extracted from natural sources using ILs as alternative liquid reagents (Figure S4 and Table 7).
Psoralen (compound 203) was the critical active component in Psoralea corylifolia L. [142] and Ficus carica L. [143], usually extracted from the plant materials with ethanol-water [144,145] and subsequently purified by multiple chromatographic steps [146]. Wang and co-workers [143] optimized the method by transformation and purification of psoralen from Ficus carica L. leaves using pH-dependent IL ([Bmim]Br). The yield of psoralen obtained in this way was 30.21 mg/g, increasing 2.44-folds as opposed to that of conventional ethanol-citric acid method without ILs. Besides, in this example, there was no participation of organic solvent, such as methanol and ethanol in the process of extraction, making the proposed method more environmentally friendly.
Furthermore, Liu et al. [147] proposed a novel extraction process for the preparation of aesculin (compounds 207) from Cortex fraxini using ionic liquid [C4mim]Br in 2015. Under the optimal conditions, the extraction efficiency of aesculin reached to 18.70 mg/g, which was 6-fold higher than that of the conventional technique refluxing with 75% ethanol-water [148].

3.5. Quinones (Compounds 216–233)

Quinones were a kind of compounds with a fully conjugated cyclic dione structure. Usually, they consisted of four types of skeletons: benzoquinone type, naphthoquinone type, phenanthraquinone type, and anthraquinone type. There have been 18 quinones extracted with ionic liquids in recent findings (Figure S5 and Table 8).
Tanshinone IIA (compound 224) is one of the major components in the traditional Chinese medicine Danshen (Radix Salvia miltiorrhiza) [156]. Ethanol was usually used to extract tanshinone IIA under reflux [157]. However, the structure might be broken down because of the high temperature [158]. Hence, Liu and co-workers [159] selected 0.5 M IL (1-octyl-3-methylimidazolium hexafluorophosphate) in ethanol as solvent, to get tanshinone IIA from Danshen based on the ultrahigh pressure extraction. The yield of tanshinone IIA was 37.4 mg/g, which was 1.33-fold higher than that of the extraction method without ILs. Meanwhile, this approach potently cut the time from 120 min (with methanol) to 2 min (with ILs).
To explore mild and efficient techniques for separation and purification of aloe-emodin (compound 217) from Aloe vera L., Tan et al. [160] evaluated the effects of the IL anion (Br−, BF4− and N[CN]2−), the side chain length of cation alkyl in the [CnC1im]+ series, the extraction time, and the biomass-solvent ratio in the extraction of aloe-emodin. Under the optimal conditions, the extraction efficiency of aloe-emodin was 92.34%, increasing three folds compared with that of the heating reflux extraction with toluene [165]

3.6. Others (Compounds 234–236)

We also summarize three lactone compounds (compounds 234–236, Figure S6 and Table 9) extracted with ILs. In order to improve the extraction process and develop a greener process, Chi et al. [166] investigated a MAE method to extract senkyunolide I (compound 234), senkyunolide H (compound 235) and Z-ligustilide (compound 236) from Ligusticum chuanxiong Hort., using two ILs N,N-dimethyl-N-(2-hydroxyethoxyethyl) ammonium propionate (DMHEEAP) and N,N-dimethyl (cyanoethyl) ammonium propionate (DMCEAP) as solvents. The result showed that the MAE of the three target lactones using ILs took less time (within 5 min), instead of 74 min [167] extracted by high-pressure ultrasonic-assisted without IL.

4. Summary

In this review, we summarized 236 natural products isolated from plants with ILs based methods reported in 169 references. All the typical and important bioactive types of NPs were included, such as flavonoids (compounds 1–65), alkaloids (compounds 66–129), terpenoids (compounds 130–187), phenylpropanoids (compounds 189–215), quinones (compounds 216–233) and others (compounds 234–236). It was clear that ILs could be tailored for the extraction of special strutures. Depending on their unique properties, ILs present advantages in destroying the cell walls and capturing the targets by chemical selectivity so as to extract and efficiently enrich the products in a short time. However, the economic cost of some special ILs restricted their large scale of use for industry. In conclusion, ILs might serve as an accelerator for natural products chemistry research in the future.

Supplementary Materials

The following are available online at https://www.mdpi.com/1420-3049/23/7/1765/s1, Figure S1: The structures of flavonoids extracted from natural sources using ILs or IL solutions. Figure S2: The structures of alkaloids extracted from natural sources using ILs or IL solutions. Figure S3: The structures of terpenoids extracted from natural sources using ILs or IL solutions. Figure S4: The structures of phenylpropanoids extracted from natural sources using ILs or IL solutions. Figure S5: The structures of quinones extracted from natural sources using ILs or IL solutions. Figure S6: The structures of other compounds extracted from natural sources using ILs or IL solutions.

Funding

The work was supported partially by National Natural Science Foundation of China (Grant No. 81473108, 81673323).

Conflicts of Interest

The authors declare no conflict of interest.

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Table
Table 1. Name and respective acronym of the cation-anion combinations in ILs.
Table 1. Name and respective acronym of the cation-anion combinations in ILs.
NameAcronymNameAcronym
benzothiazoleHBth+methanesulfonic acidCH3SO3−
1-alkyl-3-methylimidazoliumCnmim+dicyanamideN(CN)2−
1-hydroxyethyl-3-methylimidazoliumC2OHmim+tetrafluoroborateBF4−
choline alanineCh+bromideBr−
1-butyl-3-methylimidazoliumBmim+tetrachloroferrateFeCl4-
1-hexyl-3-methylimidazoliumHmim+bromotrichloroferrateFecl3Br−
1-octyl-3-methylimidazoliumOmim+Leuleucine−
2,2′-bipyridylBPy+chlorideCl−
3-methylimidazoliumMim+hexafluorophosphatePF6−
1-(4-sulfonylbutyl)-3-methylimidazoliumHO3S(CH2)4mim+hydrogenosulphateHSO4−
1-ethyl-3-methylimidazoliumEmim+acetic acidOAc−
1-methylimidazolium-p-sulfonatePr mim+bistrifluorosulfonimideNTf2−
N-alkyl-hexafluorophosphateCntr+L-aspartic acidL-ASP−
tri-n-butylamineTBA+1-ethyl-3-methylimidazolium methylphosphonate(MeO)(H)PO2−
1-butyl-3-methylimidazoliumCnCnim+methoxyacetateMOAc−
N,N-diethyl-N-methyl-N-(2-methoxyethyl)ammoniumDEME+p-toluenesulfonic acidp-TSA−
1-dodecyl-3-methylimidazoleDomim+
1-methyl-3-(3-sulfopropyl)-imidazoliumPSmim+
1-butyl-1-methylpyrrolidiniumC4C1pyr+
Table
Table 2. The application of ILs on extraction of the flavonoids fraction, and polysaccharides fraction.
Table 2. The application of ILs on extraction of the flavonoids fraction, and polysaccharides fraction.
Active FractionTypes of ILsMethod of ExtractionSourcesReferences
flavonoids fraction[HBth][CH3S03]MAEBroussonetia Papyrifera (L.) L′ Hér. ex Vent.[21]
[C4mim][N(CN)2]IL-UAE coupled with IL-ABS and back-extractionApocynum venetum L.[25]
[C4mim]Claqueous two-phase systemPhellinus igniarius (L. ex Fr.) Quel[27]
[Bmim]BrMAEBauhinia Championii (Benth.) Benth.[28]
[Bmim]BrMAEMalus Micromalus Makino[29]
[Ch][Leu]maceration Citrus reticulata Blanco cv. Ponkan[30]
[Bmim]BF4UMAEDendrobium nobile L.[31]
[C8mim]BF4, [C4mim] BF4aqueous two-phase systemGinkgo biloba L.[32]
[Bmim]ClMAEPunica granatum L. [33]
[Bmim]BrMAESmilax glabra Roxb.[34]
[Bmim]Claqueous two-phase systemCynoglossum zeylanicum (Vahl) Thunb. ex Lehm. [35]
[Bmim]BrMAEPueraria lobata (Willd.) Ohwi[36]
[Bmim]BF4aqueous two-phase systemCrataegus Pinnatifida Bunge[37]
(Hmim)(PF6)aqueous two-phase systemSelaginella doederleinii Hieron trachyphylla (Warb.) X.C.Zhang[38]
[C4MIM][PF6]liquid−liquid extractionCrataegus Pinnatifida Bunge[39]
[Bmim]BrMAEPueraria lobata (Willd.) Ohwi[40]
MAE: microwave-assisted extraction, UAE: ultrasound-assisted extraction, UMAE: ultrasound and microwave-assisted extraction, MPDE: multi-phase dispersive extraction, RSM: response surface method, IAE: infrared-assisted extraction.
Table
Table 3. The application of ILs on extraction of polysaccharides fraction.
Table 3. The application of ILs on extraction of polysaccharides fraction.
Active FractionTypes of ILsMethod of ExtractionSourcesReferences
polysaccharide fraction[Bmim]BF4aqueous two-phase systemCrataegus Pinnatifida Bunge[37]
[Bmim]BF4aqueous two-phase systemAloe vera (Haw.) Berg[46]
1-(3-methoxypropyl)-3-methylimidazolium ethyl ethylphosphonateliquid−liquid extractionCryptomeria fortunei Hooibrenk ex Otto et Dietr.[47]
SilprImNH2Clmaceration Laminaria Japonica[48]
[C4mim]BF4UAEZingiber officinale Roscoe[49]
1-alkyl-3-methylimidazolium phosphonate and phosphinate-type ionic liquidsliquid−liquid extractionBoehmeria gracilis C. H. Wright[50]
Table
Table 4. The flavonoids extracted from natural sources using ILs or IL solutions by different extraction techniques.
Table 4. The flavonoids extracted from natural sources using ILs or IL solutions by different extraction techniques.
CompoundsTypes of ILsMethods of ExtractionSourcesReferences
rutin (1)SilprBImCl, [Bmim]Br, [C4mim]Br, [Bmim]BF4[Hmim]Br, [Hmim]BF,SPE, MAE, UMAEArtemisia capillaris Thunb, Saururus chinensis (Lour.) Bail., Xanthium sibiricum Patr., Tamarix Chinensis Lour.[54,55,56,59,60,61,62]
baicalein-7-O-glucoside (24), baicalein-7-O-diglucoside (25)[C4mim][PF6]aqueous two-phase systemVeratrum stenophyllum Diels[59]
quercetin (2)SilprBImCl, SilprImNH2, SilprPy, SilmPS, SiImBr, [C4mim]Br, [Bmim] Br, [Hmim] Br, [BPy]Br [HO3S(CH2)4mim]-HSO4MDSPE, UMAE, MAEArtemisia capillaris Thunb, Xanthium sibiricum Patr, Toona sinensis (A. Juss.) Roem., Ginkgo bilobe L.[54,63,64,65]
kaempferol-3-O-β-D-glucoside (5)Mim, [Bmim] Br, [Hmim] Br, [BPy]Br, [HO3S(CH2)4mim]HSO4MAEHippophae rhamnoides L., Toona sinensis (A. Juss.) Roem, Ginkgo bilobe L.[64,65]
isorhamnetin (22)[HO3S(CH2)4mim]HSO4MAE,Ginkgo biloba L.[65]
hesperidin (3), hyperoside (4)[C6mim][BF4]MAESorbus tianschanica Rupr.[66]
orientin (6), vitexin (7), genistin (8), isovitexin (9), luteolin-6-C-β-D-glucopyranosyl-8-C-a-L-arabinopyranoside (10), luteolin-6-O-α-L-arabinopyranosyl-8-O-α-D-glucopyranoside (11), apigenin-6,8-di-O-α-L-arabinopyranoside (12), apigenin-8-O-α-L-arabinoside (13)[C4MIM]Br, [C6MIM]Br, [C8mim]BrMAE, cavitation-assisted extractionCajanus cajan (L.) Millsp., Glycine max (L.) Merr.[67,68,69]
ononin (14), daidzin (15), biochanin A (16), formononetin (17), puerarin (18), genistein (19), daidzein (20)BMImBF4, 1-butyl-3-methylimidazolium bromide, [Bmim][PF6], [Hmim][PF6], [Omim][PF6], [Bmim][NTf2], [C6min]Br, [C8mim]BrMAE, liquid−liquid extraction, UAE, cavitation-assisted extractionPueraria lobata (Willd.) Ohwi, Glycine max (L.) Merr., Cajanus cajan (L.) Millsp.[68,69,70,71,72]
glycitein (42)[BMIm][PF6], [HMIm][PF6], [OMIm][PF6], [BMIm][NTf2],liquid−liquid extractionGlycine max (L.) Merr.[72]
fisetin (21), kaempferide (23)[C4mim][PF6], [C6mim][PF6], [C8mim][PF6], 1-butyl-3-methylimidazolium bromidethree phase micro extraction, MAERheum officinale Baill., Coptis chinensis Franch., Pueraria lobata (Willd.) Ohwi[71,73]
pelargonin (26), cyanidin (27), peonidin (28), petunidin (29), malvidin (30)[C2mim]OAcaqueous two-phase systemsVitis vinifera L.[74]
luteolin (31), apigenin (32)[Bmim][MS], [C12mim]Br, [C8mim]BrUAE, cavitation-assisted extractionApium graveliens L., Chrysanthemum morifolium Ramat, Cajanus cajan L. Millsp[58,69,75]
kaempferide (53), acacetin (54)[C12mim]BrUAEChrysanthemum morifolium Ramat.[75]
tectorigenin (33), iristectorigenin A (34), irigenin (35), irisflorentin (36)[Emim][BF4]UAEBelamcanda chinensis (L.) Redouté[76]
myricetin (37), amentoflavone (38)1-oxyl-3-methylimidazolium bromide, [Emim][Cl], [Bmim][Cl], [Hmim][Cl], [Omim][Cl], [Dmim]Br, 1-bromodecane, 1-vinylimidazoleMPDE, SPE, UAE, SPEChamaecyparis obtuse (Sieb.et Zucc) Endl[77,78,79,80]
dihydrokaempferol (60)[Dmim]BrUAEChamaecyparis obtuse (Sieb.et Zucc) Endl[79]
catechin (39), epigallocatechin (40), epigallocatechin gallate (41)[C2mim][Br]heat extractionElaeis guineensis Jacq.[81]
rhodiosin (43), rhodionin (44), herbacetin (45)[BMIM]Cl, EMIMBaqueous two-phase systems, UAERhodiola rosea L.[82,83]
baicalin (46), wogonoside (47)[C4mim][PF6]aqueous two-phase systemsScutellaria baicalensis Georgi[84]
quercitrin (48)molecularly imprinted anion-functionalized poly(ionic liquid)s, [Emim][Cl], [Bmim][Cl], [Hmim][Cl], [Omim][Cl], [DMIM]Br, 1-bromodecane, 1-vinylimidazoleMPDE, SPEChamaecyparis obtuse (Sieb.et Zucc)Endl[78,79,80,85]
herbacetin-3-O-β-d-glucopyranosyl-7-O-α-l-rhamnopyranoside (49), kaempferol-3-O-β-d-glucopyranosyl-7-O-α-l-rhamn-opyranoside (50), kaempferol 3-O-β-d-glucopyranoside-(2→1)-α-d-xylopyranoside (51), herbacetin-8-O-β-d–glucopyranoside (52)1-ethyl-3-methylimidazoliumbromideSPERhodiola rosea L.[86]
baicalein (55), wogonin (56)[C8mim]BrUAEScutellaria baicalensis Georgi.[87]
procyanidin(57), anthocyanin-3-O-acetylmonoglucosides (58), anthocyanin-3-(6-O-p-coumaroyl)monoglucosides (59)[C4mim][Br], [C2mim][Br], [mim][HSO4], [sC4mim][HSO4]liquid−liquid extractionVitis vinifera L.[88]
neohesperidin (61), naringin (62)[Bmim]BF4, [Ch][Bic]SPE, liquid−liquid extractionVaccinium Spp[89]
hyperin (63)[C4mim]BF4MAEPopulus euphratica Oliv.[90]
kaempferol-3,4′-di-O-β-D-glucoside (64), kaempferol-3-O-β-D-(2-O-β-D-glucosyl)-glucopyranoside (65)[E mim][Cl], [Pr mim ][Cl], [B mim][Cl], [C5 mim][Cl], [E mim ][Br], [Pr mim][Br], [B mim][Br], [C5 mim ][Br], [EMIM][BF4], [Pr mim][BF4], [B mim ][BF4] and [C5mim][BF4]aqueous two-phase systemsBrassica napus L.[91]
Table
Table 5. The alkaloids extracted from natural sources using ILs or IL solutions by different extraction techniques.
Table 5. The alkaloids extracted from natural sources using ILs or IL solutions by different extraction techniques.
CompoundsTypes of ILsMethods of ExtractionSourcesReferences
sinomenine (66)[C2OHmim]FeCl4UAEAdenia chevalieri Gagnep[99]
anisodamine (85), atropine (86), scopolamine (87), aposcopolamine (88), scopoline (89)[C3tr][PF6]macerationPhysochlainae infundibularis Kuang (Solanaceae)[100]
protopine (67), allocryptopine (68), sanguinarine (69), chelerythrine (70), dihydrochelerythrine (71), dihydrosanguinarine (72)[C6mim][BF4], [K][PF6], 1-butyl-3-methylimidazole tetrafluoroborateUAE, IAEMacleaya cordata (Willd.) R. Br., Dicranostigma leptopodum (Maxim.) Fedde[102,103]
quinine (96), cinchonidine (97), lycorine chloride (112)[C4MIM]ClIAE(Howard) Moens ex Trim.[103]
aconitine (73), mesaconitine (74), hypaconitine (75)1-ethyl-3-methylimidazolium tetrafluoroborateUAEAconitum carmic-haeli Debx.[104]
coptisine (76), palmatine (77), berberine (78), boldine (79), chelidonine (80), papaverine (81), emetine (82), columbamine (83), magnoflorine (84)1-butyl-3-methylimidazolium Tetrafluoroborate, 1-butyl-3-methylimidazole tetrafluoroborate, 1-butyl-3-methylimidazolium bromideIAE, UAECoptis chinensis Franch., Dicranostigma leptopodum (Maxim.) Fedde, Phellodendron amurense Rupr.[99,105]
jatrorrhizine (123)1-butyl-3-methylimidazolium bromideUAEPhellodendron amurense Rupr[105]
theobromine (90), theophylline (91)1-methylimidazole based ILSPECamellia sinensis (L.) O. Ktze.[106]
pronuciferine (92), N-nornuciferine (93), nuciferine (94), roemerine (95)[C4mim][BF4]aqueous two-phase systemNelumbo nucifera Gaertn[107]
galantamine (98), narwedine (99), N-desmethylgalantamine (100), ungiminorine (101)[C4C1im]ClSPELeucojum aestivum L. (Amaryllidaceae)[108]
brucine (102), cinchonine (103), glaucine (104), codeine (105), laudanosine (106), noscapine (107)1-butyl-2,3-dimethylimidazolium tetrafluoroborate, [C4C1im][Ace]IAE, macerationGlaucium flavum Cr.[103,109]
liensinine (108), isoliensinine (109), romerine (110), neferine (111)[C4mim][PF6]aqueous two-phase systemsNelumbo nucifera Gaertn[110]
rhynchophylline (113), pteropodine (114), isomitraphylline (115), isopteropodine (116)BmimMAERanunculus ternatus Thunb.[111]
benzoylmesaconine (117), benzoylaconine (118), benzoylhypaconine (119), mesaconitine (120), hypaconitine (121), aconitine (122)[C6mim]Braqueous two-phase systemAconitum carmichaeli Debx[112]
matrine (124), oxymatrine (125)silica-confined ionic liquidsSPESophora flavescens Ait[113]
vinblastine (126), catharanthine (127), vindoline (128)[Amim]BrUAECatharanthus roseus[114]
bilobalide (129)[C4mim]ClmacerationGinkgo biloba L.[115]
Table
Table 6. The terpenoids extracted from natural sources using ILs or IL solutions by different extraction techniques.
Table 6. The terpenoids extracted from natural sources using ILs or IL solutions by different extraction techniques.
CompoundsTypes of ILsMethods of ExtractionSourcesReferences
paclitaxel (169)MIL [C4mim]FeCl3BrUAETaxus chinensis (Pilger) Rehd.[125]
α-pinene (130), 1,8-cineole (131), linalool (132), terpinen-4-ol (133), Borneol (134), α-terpineol (135), bornyl acetate (136), cubebene (149), α-copaene (150), bergamotene (151), β-caryophyllene (152), humulene (153), calamenene (154), cadina-1,4-diene (155)Benzalconium lactate, Didecyldimethyl lactate, Benzalconium nitrate, Didecyldimetthyl nitrate, Tris(2-hydroxyethyl)methylamonium methylsulfateUAECinnamomum cassia Presl[126]
scroside B (137), hemiphroside A (138), scroside A (139), scroside C (140), scroside D (141), scroside I (142), picroside (158), picroside III (159), picroside I (160), picroside II (161), specioside (162), 6-O-E-feruloyl catalpol (163), 2-O-β-D-glucopyranosyl-3,16,20, 25-tetrahydroxy-9-methyl-19-norlanosta-5,23-dien-22-one (170), 2-O-β-D-glucopyranosyl-3,16,20-trihydroxy-25-acetoxy-9-methyl-19-norlanosta-5,23-dien-22-one (171)[BMIM][BF4]UAEPicrorhiza scrophulariiflora Pennell[127]
ionone (143), linalool oxide pyranoid (144), linalool oxide furanoid (145)[C2mim][(MeO)(H)PO2)]macerationOsmanthus fragrans (Thunb.) Lour. Cv. Aurantiacus[128]
geranial (146), neral (147), geraniol (148)[C4mim]Cl [C2mim][(MeO)(H)PO2)], [C2mim][(MeO)(H)PO2], [DEME]Cl, [DEME][MOAc].macerationCymbopogon citratus (D. C.) Stapf, Backhousia citriodora[129,130]
cynaropicrin (156)1-alkyl-3-methylimidazolium chlorideliquid-liquid extractionCynara, cardunculus L.[131]
paeoniflorin (157)[Bmim]BrMAEPaeonia suffruticosa Andr[132]
forskolin (168)tetramethyl guanidium lactateUAEColeus forskohlii (Willd.) Briq[133]
ganoderic-acid ∑ (172)[C4mim]Cl [C2mim][(MeO)(H)PO2)]UAEGanoderma lucidum (Leyss. Ex Fr.) Karst.[134]
ursolic (173), ursolic (174), betulinic acids (175)[C4C1im][N(CN)2], [C4C1im][TOS], [C4C1im][SCN], [C4C1im][C2H5SO4], [C4C1py][N(CN)2], and [C4C1pyr]Cl,liquid-liquid extractionMalus pumila Mill.[135]
3-oxotirucalla-7,24Z-dien-27-oic acid (176), 3α-hydroxytirucalla-7,24Z-dien-27-oic acid (177), 3α-acetoxytirucalla-7,24Z-dien-27-oic acid (178)BmimBrMAESchinus terebinthifolius Raddi[136]
dongnoside E (179)ChCldeep eutectic solvents extractionAgave americana L.[137]
insenoside Rg1 (180), ginsenoside Re (181), ginsenoside Rf (182), ginsenoside Rb1 (183), ginsenoside Rc (184), ginsenoside Rb2 (185), ginsenoside Rd (186)[C3mim]BrUAEPanax ginseng C. A. Meyer[138]
sgenin (187)[PSmim]HSO4UAEDioscorea opposita Thunb.[139]
morroniside (164), sweroside (165), loganin (166), cornuside (167)[Domim]HSO4macerationCornus officinalis Sieb. et Zucc.[140]
Table
Table 7. The phenylpropanoids extracted from natural sources using ILs or IL solutions by different extraction techniques.
Table 7. The phenylpropanoids extracted from natural sources using ILs or IL solutions by different extraction techniques.
CompoundsTypes of ILsMethods of ExtractionSourcesReferences
schisandrin (188), schisantherin (189), deoxyschisandrin (190), γ-schisandrin (191)Bmim-BF4aqueous two-phase systemSchisandra chinensis (Turcz.) Baill.[143]
psoralen (203)[Bmim]Brliquid-liquid extractionFicus carica L.[145]
schisandrol B (192), schisanhenol (193), deoxyshisandrin (194), schisandrin C (195)[C4mim][BF4]UAESchisandra chinensis (Turcz.) Baill.[149]
rosmarinic acid (196), sodium danshensu (197), lithospermic acid (198), salvianolic acid B (199)SiO2.Im+.PF6SPESalvia miltiorrhiza Bunge[150]
schizandrin (200), schisantherin A (201), γ-schizandrin (202)[C4mim]AcmacerationSchisandra chinensis (Turcz.) Baill.[151]
magnolol (204), honokiol (205)[Bmim][BF4]UAEMagnolia officinalis Rehd. et Wils.[152]
podophyllotoxin (206)[Amim][BF4]MAEDysosma versipellis (Hance) M. Cheng ex Ying, Sinopodophyllum hexandrum (Royle) Ying[153]
aesculin (207), aesculetin (208)[C4mim]Brultrasound-microwave synergistic extractionFraxinus chinensis Roxb[147,154]
isopsoralen (209), bergapten (210), isobergapten (211), oxypeucedanin (212), imperatorin (213), osthole (214), isoimperatorin (215)[C6mim][PF6]liquid–liquid micro extractionAngelica dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. ex Franch. et Sav.[155]
Table
Table 8. The quinones extracted from natural sources using ILs or IL solutions by different extraction techniques.
Table 8. The quinones extracted from natural sources using ILs or IL solutions by different extraction techniques.
CompoundsTypes of ILsMethods of ExtractionSourcesReferences
rhein (225), danthron (226), emodin (227), chrysophanol (228)[Bmim]Cl, [Bmim]Br, [Bmim]BF4UAE, MAERheum officinale Baill.[155]
dihydrotanshinone (231), miltirone (232)1-octyl-3-methylimidazolium hexafluoro-phosphateultrahigh pressure extractionSalvia miltiorrhiza Bunge[159]
emodin (216), aloe-emodin (217), rhein (218), aloin (221)[C4mim]BF4liquid–liquid extractionAloe vera L.[160]
tashinone IIA (224)(3-aminopropyl)trimethoxysilane, 1-octyl-3-methylimidazolium hexafluoro-phosphateimprinted functionalized ionic liquid-modified silica, ultrahigh pressure extractionSalvia miltiorrhiza Bunge[159,161]
cryptotanshinone (222), tanshinone I (223)(3-aminopropyl)trimethoxysilaneimprinted functionalized ionic liquid-modified silicaSalvia miltiorrhiza Bunge[161]
chrysophanol (219), physcion (221)1-hexyl-3-methylimidazolium hexafluorophosphateliquid–liquid micro extractionRheum officinale Baill[162]
shikonin (229), β,β′-dimethylacrylshikonin (230)[C6mim][PF6]UMAELithospermum erythrorhizon Sieb. et Zucc.[163]
stibene glycoside (233)[Bth][Br], [HBth][p-TSA]liquid–liquid extractionFallopia multiflora (Thunb.) Harald.[164]
Table
Table 9. The other compounds extracted from natural sources using ILs or IL solutions by different extraction techniques.
Table 9. The other compounds extracted from natural sources using ILs or IL solutions by different extraction techniques.
CompoundsTypes of ILsMethods of ExtractionSourcesReferences
senkyunolide I (compound 234), senkyunolide H (compound 235), Z-ligustilide (compound 236)N,N-dimethyl-N-(2-hydroxyethoxyethyl)ammonium propionate, N,N-dimethyl(cyanoethyl)ammonium propionateMAELigusticum chuanxiong Hort.[166]

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Xiao, J.; Chen, G.; Li, N. Ionic Liquid Solutions as a Green Tool for the Extraction and Isolation of Natural Products. Molecules 2018, 23, 1765. https://doi.org/10.3390/molecules23071765

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Xiao J, Chen G, Li N. Ionic Liquid Solutions as a Green Tool for the Extraction and Isolation of Natural Products. Molecules. 2018; 23(7):1765. https://doi.org/10.3390/molecules23071765

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Xiao, Jiao, Gang Chen, and Ning Li. 2018. "Ionic Liquid Solutions as a Green Tool for the Extraction and Isolation of Natural Products" Molecules 23, no. 7: 1765. https://doi.org/10.3390/molecules23071765

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