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Article

Modification of Polyhedral Oligomeric Silsesquioxanes (POSS) Molecules by Ruthenium Catalyzed Cross Metathesis

by
Justyna Czaban-Jóźwiak
*,†,
Łukasz Woźniak
,
Artur Ulikowski
,
Katarzyna Kwiecińska
,
Adam A. Rajkiewicz
and
Karol Grela
*
Institute of Organic Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, PO Box 58, 01-224 Warsaw, Poland
*
Authors to whom correspondence should be addressed.
†
Current address: Functional Material Design, Discovery and Development Research Group (FMD3), Advanced Membranes and Porous Materials Center (AMPMC), Division of Physical Sciences and Engineering (PSE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia
Molecules 2018, 23(7), 1722; https://doi.org/10.3390/molecules23071722
Submission received: 17 June 2018 / Revised: 10 July 2018 / Accepted: 11 July 2018 / Published: 14 July 2018
(This article belongs to the Section Organic Chemistry)
Browse Figures
Versions Notes

Abstract

:
The scope of ruthenium (Ru)-catalyzed cross metathesis (CM) of allyl-decorated polyhedral oligomeric silsesquioxanes (POSS) was explored. A variety of different commercial and non-commercial ruthenium complexes were tested to determine that the nitro-activated Ru catalyst is optimal for this transformation. The reported transformation was used to prepare selected hybrid steroid-POSS compounds.

1. Introduction

Polyhedral oligomeric silsesquioxanes (POSS) are characterized by their remarkable cubic structure, which has received attention from scientists of different disciplines [1,2,3]. POSS can be used as precursors and components in a variety of hybrid materials for biomedical applications, such as biomedical devices, tissue engineering scaffolds, drug delivery systems, dental applications, and biological sensors [4,5,6,7,8,9,10]. The POSS molecule (Figure 1) consists of a cubic silica-oxygen core that is surrounded by eight tunable groups, one in each corner of the cube. These groups can be identical or one of them can be different, allowing for further site selective modification. The chain groups (R, X) can be substituted with a potentially unlimited number of organofunctional groups, such as alkyls, olefins, alcohols, esters, anhydrides, amines, imides, epoxides, thiols, sulfonates, silanols, and many others [11].
Olefin cross metathesis (CM) is one of the most powerful methods for preparing variously substituted alkenes [12,13,14,15]. CM is widely used as a key step in the synthesis of many chemicals from simple oils [16,17] to complex structures that exhibit biological activity [18,19,20].
CM is catalyzed by ruthenium (Ru) or molybdenum (Mo) complexes; the most common catalysts are ruthenium complexes such as Grubbs (Gr), Hoveyda-Grubbs (Hov) and Indenylidene (Ind) (Figure 2) [21].
The first cross metathesis reaction of octavinyl POSS was performed by the Feher group in 1997 employing Schrock and Grubbs catalysts [22]. Schrock catalysts were substantially more active compared to Grubbs. The authors showed that metathesis offers an important new route in the functionalization of POSS derivatives. Even though Schrock catalysts provided better results, the authors emphasized that ruthenium catalysts are the future of POSS CM. Marciniec et al. reported the first efficient CM of vinyl-POSS in the presence of a ruthenium catalyst [23,24,25]. POSS CM was also applied for the synthesis of POSS-core dendrimers [26,27]. Notably, this methodology required extremely high catalyst loading (45 mol%) of first generation Grubbs catalyst (Gr-I) [26,27].
The CM reaction of POSS derivatives might be considered the most direct method for obtaining new POSS biohybrids, which is being intensively explored in nanomedicine [4]. Herein, we report the first examples of allyl-POSS CM reaction. To achieve this transformation, a variety of commercially available ruthenium complexes, as well as a few obtained in our laboratories, were screened in two model CM reactions of allyl-POSS derivative (1), using easily reacting cis-1,4-Diacetoxy-2-butene (3) and the more challenging, electron-deficient, tert-butyl acrylate (2) as CM partners. After selecting the most efficient catalysts the utility of this method was demonstrated by the synthesis of some selected POSS-steroid conjugates.

2. Results and Discussion

The first step in the present study was to choose an appropriate catalyst and conditions. For this approach, we selected tert-butyl acrylate (2) and (Z)-diacetoxy-but-2-en (3) as the model CM partners (Table 1). The CM reactions were performed at room temperature in dichloromethane (DCM). Notably, the catalyst loading in these preliminary experiments was set at 0.5 mol%, which is substantially lower than in the previous reports on CM of POSS molecules of 45 mol%.
Almost all tested complexes (Figure 2 and Figure 3) presented some activity toward POSS CM. First generation catalysts [Ru]-1 and [Ru]-2 (Table 1, Entry 1 and 2, respectively) showed the lowest activity among the catalysts studied here. In the Indenylidene family, complexes Ind-2 (Table 1, Entry 10) and [Ru]-8 (Table 1, Entry 12) did not catalyse the process, whereas [Ru]-7 (Table 1, Entry 11) exhibited medium activity. However, those complexes perform better at elevated temperatures [28]. Complexes with SIPr N-Heterocyclic Carbene (NHC) ligands [Ru]-4 (Table 1, Entry 5), [Ru]-5 (Table 1, Entry 8), [Ru]-13 (Table 1, Entry 22), and Ru-[14] (Table 1, Entry 23) displayed higher catalytic activity toward the CM reaction in comparison to the parent catalysts [20,29]. Complexes bearing so-called “Turbo” unsaturated NHC ligand [Ru]-3 (Table 1, Entry 4) and [Ru]-6 (Table 1, Entry 9) according the literature supposed to behave similarly to SIPr-modified complexes [30]. Interestingly, in this case, we observed lower catalytic activity. A modification of the benzylidene ligand, as in the case of Nitro (Table 1, Entry 13), [Ru]-13 (Table 1, Entry 21), [Ru]-14 (Table 1, Entry 23), and [Ru]-15 [31] (Table 1, Entry 25), did not improve catalytic activity compared to parent Hov-II (Table 1, Entry 10). Similarly, the additional chelation present in the case of complexes [Ru]-9 (Table 1, Entry 15), [Ru]-10 [32,33] (Table 1, Entry 17), and [Ru]-11 (Table 1, Entry 19) did not significantly change the reaction outcome.
Next, we investigated the catalytic activity of Ru complexes bearing the NHC ligand with a more bulky naphthyl side chains (Dorta’s NHC ligands, Figure 4) [34]. This type of complexes possesses higher activity in some olefin metathesis transformations [35,36,37]. However, in the case of POSS CM, catalysts [Ru]-16 (Table 1, Entry 26), [Ru]-17 (Table 1, Entry 27), and [Ru]-18 (Table 1, Entry 28) generally displayed similar activity as the other “decorated” Hoveyda-type complexes.
For further investigation of POSS metathesis with more sophisticated CM partners, the most popular Hov-II catalyst was selected due to its commercial availability and satisfying catalytic activity. Additionally, the Nitro catalyst was selected due to its high catalytic activity toward steroids [38] as well as its commercial availability.
As these steroidal CM partners can be more challenging in terms of reactivity than a simple diacetate 3 or even acrylate 2, we expected that an increase in the reaction temperature and catalyst loading might be necessary to obtain practically useful product yields.
Reacting androsterone derivative 6 with allyl-POSS (1) (Table 2) in the previously determined optimal conditions yielded only traces (3%) of the desired product. Increasing the temperature to 45 °C and the loading of Hov-II to 2 mol% increased the yield of 7 to 36%. Further improvement was achieved by performing the reaction 100 °C in toluene to access the desired product 7 in 69% yield. Finally, when we performed the reaction in the presence of the Nitro catalyst, product 7 was obtained with 72% of yield as a mixture of Z/E isomers 20:80.
Pregnenolone derivative 8 (Table 3) react with allyl-POSS to give the functionalized POSS 9 in 29% yield using 0.5 mol% of Hov-II at room temperature. Increasing the temperature to 100 °C did not significantly improve the yield (36%), as well as applying Nitro as a catalyst (46%). However, the best result was obtained refluxing the reaction mixture in DCM for 24 h using 2 mol% of Nitro catalyst. In these conditions, the desired product 9 was obtained in 69% yield as a mixture of Z/E isomers 20:80
We were intrigued by very similar results obtained at room temperature and 100 °C using substrate 8. We hypothesized that the higher reaction temperature might facilitate both reaction between and 1 and 8 but also self CM of 1. We performed control experiments by mixing 1 with 0.5 mol% of Hov-II in toluene at 100 °C and in DCM at room temperature. Indeed, the experiment at elevated temperature resulted in 90% of the self cross metathesis product and no conversion was observed at room temperature.
Next, we employed the optimal conditions for substrate 8 to prepare estrone POSS derivative 11 (Scheme 1) that was obtained as 20:80 mixture of Z/E isomers in 62% yield.

3. Materials and Methods

3.1. General

Nuclear magnetic resonance (NMR) spectra were recorded in CDCl3 (chloroform-d) or benzene-d6 solutions (unless indicated otherwise); chemical shifts are reported in the δ scale in ppm, with the solvent signal as the internal standard (CDCl3, 1H NMR 7.26 ppm; 13C NMR 77.00 ppm, benzene-d6, 1H NMR 7.16 ppm, 13C NMR 128.06 ppm). Column chromatography was performed on Merck silica gel 60, 230–400 mesh (Darmstadt, Germany). Thin layer chromatography (TLC) was performed on aluminum sheets, Merck 60 F254 (Darmstadt, Germany). Anhydrous solvents were obtained by distillation over calcium chloride (CaCl2) (DCM, Toluene). All reactions were performed under argon (Ar) in pre-dried glassware using Schlenk techniques.

3.2. General Procedure for the Cross Metathesis of 1 with Different Partners

The catalyst was added in one portion to a solution of propyl-POSS and appropriate partner in DCM/Toluene (4 mL). The resulting mixture was stirred in an appropriate temperature under an argon atmosphere. The solvent was removed under reduced pressure. The crude product was purified by flash chromatography (c-hexane/EtOAc) to obtain pure product.

3.3. 4-(POSS)but-2-en-1-yl acetate (4)

1H NMR (500 MHz, CDCl3): δ, 5.79–5.70 (m, 1H), 5.66 (dtt, J = 11.4, 8.6, 1.4 Hz, 1H), 5.55–5.45 (m, 1H), 4.61 (dd, J = 6.8, 1.4 Hz, 1H), 4.48 (dd, J = 6.7, 1.1 Hz, 2H), 2.06 (s, 1H), 2.04 (s, 2H), 1.85 (dpd, J = 13.4, 6.7, 2.3 Hz, 7H), 1.66 (dd, J = 8.6, 1.4 Hz, 1H), 1.61 (dd, J = 7.9, 1.3 Hz, 2H), 0.96 (dd, J = 6.6, 1.0 Hz, 42H), 0.63–0.58 (m, 14H) ppm. 13C NMR (126 MHz, CDCl3): δ, 171.1, 171.0, 130.7, 128.6, 124.2, 122.9, 77.4, 77.3, 77.1, 76.9, 65.6, 60.6, 25.9, 25.8, 25.8, 24.0, 22.9, 22.6, 22.5, 21.2, 18.4, 14.6, 1.2, 0.1 ppm (Supplementary Materials). IR (film, DCM) ν 2954, 2927, 2907, 2870, 1745, 1465, 1401, 1383, 1366, 1332, 1230, 1169, 1107, 1038, 964, 838. EA Anal. Calcd. For C34H72O14Si8: C, 43.93; H, 7.81; found C, 43.77; H, 7.98. MS (ESI): m/z [M + Na]+: 951.

3.4. tert-butyl 4-(POSS)but-2-enoate (5)

1H NMR (500 MHz, CDCl3): δ, 6.86 (dt, J = 15.4, 8.5 Hz, 1H), 5.67 (dt, J = 15.4, 1.4 Hz, 1H), 1.85 (dpd, J = 13.5, 6.8, 1.5 Hz, 7H), 1.75 (dd, J = 8.5, 1.4 Hz, 2H), 1.47 (s, 9H), 0.95 (dd, J = 6.6, 1.0 Hz, 43H), 0.63–0.58 (m, 14H) ppm. 13C NMR (126 MHz, CDCl3): δ, 166.1, 143.0, 123.3, 79.8, 79.7, 28.5, 28.4, 25.9, 25.8, 24.1, 24.0, 24.0, 22.7, 22.6, 22.5, 22.2, 22.1, 19.4, 1.2, 0.2 ppm (Supplementary Materials). IR (film, DCM) ν 2955, 2932, 2907, 2870, 1714, 1646, 1465, 1401, 1383, 1367, 1326, 1296, 1230, 1213, 1168, 1106, 1040, 982, 839. EA Anal. Calcd. For C36H76O14Si8: C, 45.15; H, 8.00; found C, 45.03; H, 7.93. MS (ESI): m/z [M + Na]+: 979.

3.5. (10R,13S)-10,13-dimethyl-1,2,3,4,7,8,9,10,11,12,13,14,15,16-tetradecahydrospiro[cyclopenta[a] phenanthrene-17,2’-[1,3]dioxolan]-3-yl 6-(POSS)hex-4-enoate (7)

1H NMR (400 MHz, C6D6): δ, 5.76–5.62 (m, 1H), 5.59–5.44 (m, 1H), 5.35–5.26 (m, 1H), 4.87 (ddt, J = 11.1, 8.4, 5.5 Hz, 1H), 3.61–3.46 (m, 4H), 2.58–2.46 (m, 1H), 2.41 (t, J = 6.9 Hz, 2H), 2.36–2.30 (m, 1H), 2.18–1.98 (m, 9H), 1.88 (dddd, J = 17.2, 14.9, 7.3, 4.0 Hz, 4H), 1.80–1.69 (m, 3H), 1.67–1.53 (m, 5H), 1.46 (dd, J = 11.4, 3.2 Hz, 3H), 1.36 (td, J = 13.8, 13.0, 5.0 Hz, 3H), 1.16–1.04 (m, 47H), 0.96 (d, J = 1.6 Hz, 3H), 0.91 (t, J = 2.3 Hz, 3H), 0.88–0.80 (m, 14H) ppm. 13C NMR (101 MHz, CDCl3): δ, 171.9, 139.8, 129.8, 124.6, 122.7, 119.6, 73.8, 65.2, 64.6, 50.9, 50.3, 46.1, 38.8, 37.2, 36.9, 34.9, 34.7, 32.4, 31.7, 30.9, 28.8, 28.3, 25.9, 24.5, 23.2, 23.1, 22.9, 20.9, 19.4, 18.5, 14.6 ppm (Supplementary Materials). IR (film, DCM) ν 3444, 2925, 2856, 1733, 1671, 1462, 1378, 1307, 1255, 1228, 1170, 1109, 1040, 959, 903, 881.

3.6. (13S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a] phenanthren-3-yl-6-(POSS)hex-4-enoate (9)

1H NMR (400 MHz, C6D6): δ, 5.94–5.82 (m, 0.2 × 1H), 5.76–5.65 (m, 1H), 5.62–5.52 (m, 0.8 × 1H), 5.35 (dt, J = 5.6, 1.8 Hz, 1H), 3.45–3.34 (m, 1H), 2.30–2.21 (m, 2H), 2.20–2.03 (m, 9H), 1.99–1.87 (m, 2H), 1.86–1.77 (m, 2H), 1.75–1.65 (m, 3H), 1.63–1.53 (m, 2H), 1.50–1.36 (m, 5H), 1.31 (s, 3H), 1.14–1.06 (m, 44H), 0.96 (s, 3H), 0.93 (s, 3H), 0.89–0.83 (m, 14H) ppm. 13C NMR (101 MHz, C6D6): δ, 141.3, 126.8, 125.6, 121.6, 74.9, 74.8, 74.3, 71.7, 59.2, 58.9, 58.8, 57.3, 50.6, 50.6, 47.6, 43.3, 43.1, 43.1, 42.9, 41.4, 40.7, 40.6, 37.7, 36.8, 32.3, 32.2, 31.7, 27.8, 27.2, 27.0, 26.0, 26.0, 25.9, 24.5, 24.4, 24.3, 24.2, 23.1, 23.0, 22.8, 22.5, 21.4, 21.4, 19.5, 18.6, 14.5, 14.0, 13.9, 13.8 ppm (Supplementary Materials). IR (film, DCM) ν 3387, 2954, 2871, 1708, 1465, 1401, 1382, 1366, 1333, 1229, 1110, 954, 837. MS (TOF ES): m/z [M + Na]+: 1210.53

3.7. ((13S,17R)-13-methyl-17-(4-(POSS)but-2-en-1-yl)-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol (11)

1H NMR (400 MHz, CDCl3): δ, 7.30–7.26 (m, 1H), 6.88–6.77 (m, 2H), 5.69–5.56 (m, 0.2 × 1H), 5.63–5.55 (m, 0.2 × 1H), 5.54–5.45 (m, 0.8 × 1H), 5.44–5.35 (m, 0.8 × 1H), 2.96–2.84 (m, 2H), 2.62–2.54 (m, 2H), 2.53–2.46 (m, 1H), 2.46–2.36 (m, 2H), 2.29 (t, J = 10.9 Hz, 1H), 2.21–2.07 (m, 1H), 2.07–1.93 (m, 3H), 1.86 (dpd, J = 13.4, 6.7, 2.0 Hz, 8H), 1.69–1.58 (m, 3H), 1.58–1.38 (m, 6H), 1.05–0.83 (m, 46H), 0.65–0.56 (m, 14H) ppm. 13C NMR (101 MHz, CDCl3): δ, 220.9, 172.2, 148.7, 138.1, 137.4, 128.2, 126.7, 126.5, 125.3, 124.8, 121.7, 121.7, 118.9, 118.8, 50.6, 48.1, 44.3, 38.1, 36.0, 34.7, 34.5, 31.7, 29.5, 28.4, 26.5, 25.9, 25.8, 24.0, 23.9, 23.9, 22.7, 22.6, 22.6, 22.5, 21.7, 18.2, 13.9, 1.2 ppm (Supplementary Materials). IR (film, DCM) ν 3455, 3077, 2952, 2928, 2870, 1739, 1641, 1608, 1583, 1494, 1453, 1417, 1369, 1335, 1260, 1226, 1114, 1009, 915. MS (TOF ES): m/z [M + Na]+: 1204.44

4. Conclusions

In summary, we explored the ruthenium-catalyzed cross metathesis reactions between allyl-POSS and five alkenes, including three steroid derivatives. We showed that, even for such challenging partners and relatively mild conditions, such as 0.5–2 mol% of catalyst at DCM or toluene at RT to 100 °C, are sufficient to perform an efficient CM reaction with POSS derivatives. The best catalysts for these transformations were Hov-II and Nitro complexes.

Supplementary Materials

The following are available online. Figure S1: 1H NMR of compound 4; Figure S2: 13C NMR of compound 4; Figure S3: 1H NMR of compound 5; Figure S4: 13C NMR of compound 5; Figure S5: 1H NMR of compound 7; Figure S6: 13C NMR of compound 7; Figure S7: 1H NMR of compound 9; Figure S8: 13C NMR of compound 9; Figure S9: 1H NMR of compound 11; Figure S10: 1H NMR of compound 11.

Author Contributions

Methodology: J.C.J., Ł.W.; Formal Analysis, J.C.J., Ł.W.; Investigation, J.C.J., Ł.W., A.U., K.K., A.A.R.; Writing: original draft preparation, J.C.J.; Writing: review and editing, J.C.J., Ł.W. and K.G.

Funding

This research was funded by The National Science Center, Poland grant number 2011/01/N/ST5/05638.

Acknowledgments

The authors would like to thank Erik Abbenhuis and Gijsbert Gerritsen from Hybrid Catalysis BV for their generous donation of the POSS derivatives used in this studies.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Hartmann-Thompson, C. Applications of polyhedral oligomeric silsesquioxanes; Springer: Dordrecht, The Netherlands, 2011; p. 420. [Google Scholar]
  2. Markovic, E.; Constantopolous, K.; Matisons, J.G. Polyhedral oligomeric silsesquioxanes: From early and strategic development through to materials application. Appl. Polyhedr. Oligomeric Silsesquioxanes 2011, 3, 1–46. [Google Scholar]
  3. Pielichowski, K.; Njuguna, J.; Janowski, B.; Pielichowski, J. Polyhedral oligomeric silsesquioxanes (POSS)-containing nanohybrid polymers. In Supramolecular polymers polymeric betains oligomers; Donnio, B., Guillon, D., Harada, A., Hashidzume, A., Jaeger, W., Janowski, B., Kudaibergenov, S., Laschewsky, A., Njuguna, J., Pielichowski, J., et al., Eds.; Springer: Berlin, Germany, 2006; Volume 201, pp. 225–296. [Google Scholar]
  4. Ghanbari, H.; Cousins, B.G.; Seifalian, A.M. A nanocage for nanomedicine: Polyhedral oligomeric silsesquioxane (POSS). Macromol. Rapid Commun. 2011, 32, 1032–1046. [Google Scholar] [CrossRef] [PubMed]
  5. John, Ł.; Malik, M.; Janeta, M.; Szafert, S. First step towards a model system of the drug delivery network based on amide-POSS nanocarriers. RSC Adv. 2017, 7, 8394–8401. [Google Scholar] [CrossRef] [Green Version]
  6. John, L.; Janeta, M.; Szafert, S. Synthesis of cubic spherosilicates for self-assembled organic-inorganic biohybrids based on functionalized methacrylates. New J. Chem. 2018, 42, 39–47. [Google Scholar] [CrossRef]
  7. Janeta, M.; John, L.; Ejfler, J.; Lis, T.; Szafert, S. Multifunctional imine-POSS as uncommon 3D nanobuilding blocks for supramolecular hybrid materials: Synthesis, structural characterization, and properties. Dalton Trans. 2016, 45, 12312–12321. [Google Scholar] [CrossRef] [PubMed]
  8. Janeta, M.; John, L.; Ejfler, J.; Szafert, S. High-yield synthesis of amido-functionalized polyoctahedral oligomeric silsesquioxanes by using acyl chlorides. Chemistry-a Eur. J. 2014, 20, 15966–15974. [Google Scholar] [CrossRef] [PubMed]
  9. John, Ł. Selected developments and medical applications of organic–inorganic hybrid biomaterials based on functionalized spherosilicates. Mater. Sci. Eng. C 2018, 88, 172–181. [Google Scholar] [CrossRef] [PubMed]
  10. Kannan, R.Y.; Salacinski, H.J.; Butler, P.E.; Seifalian, A.M. Polyhedral oligomeric silsesquioxane nanocomposites: The next generation material for biomedical applications. Account. Chem. Res. 2005, 38, 879–884. [Google Scholar] [CrossRef] [PubMed]
  11. Wu, J.; Mather, P.T. POSS polymers: Physical properties and biomaterials applications. Polym. Rev. 2009, 49, 25–63. [Google Scholar] [CrossRef]
  12. Blackwell, H.E.; O’Leary, D.J.; Chatterjee, A.K.; Washenfelder, R.A.; Bussmann, D.A.; Grubbs, R.H. New Approaches to Olefin Cross-Metathesis. J. Am. Chem. Soc. 2000, 122, 58–71. [Google Scholar] [CrossRef] [Green Version]
  13. Vernall, A.J.; Abell, A.D. Cross metathesis of nitrogen-containing systems. Aldrichimica Acta 2003, 36, 93–105. [Google Scholar] [CrossRef]
  14. Chatterjee, A.K.; Choi, T.-L.; Sanders, D.P.; Grubbs, R.H. A general model for selectivity in olefin cross metathesis. J. Am. Chem. Soc. 2003, 125, 11360–11370. [Google Scholar] [CrossRef] [PubMed]
  15. Zukowska, K.; Grela, K. Cross metathesis. In Olefin Metathesis: Theory and Practice; Grela, K., Ed.; John Wiley & Sons: Hoboken, NJ, USA, 2014; pp. 39–83, (and citation therein). [Google Scholar]
  16. Czaban, J.; Schertzer, B.M.; Grela, K. Low catalyst loadings in self-metathesis of 1-dodecene. Adv. Synth. Catal. 2013, 355, 1997–2006. [Google Scholar] [CrossRef]
  17. Kajetanowicz, A.; Sytniczuk, A.; Grela, K. Metathesis of renewable raw materials-influence of ligands in the indenylidene type catalysts on self-metathesis of methyl oleate and cross-metathesis of methyl oleate with (Z)-2-butene1,4-diol diacetate. Green Chem. 2014, 16, 1579–1585. [Google Scholar] [CrossRef]
  18. Olszewski, T.K.; Figlus, M.; Bieniek, M. Olefin metathesis: A versatile synthetic tool for use in preparation of active pharmaceutical ingredients. Chimica Oggi-Chemistry Today 2014, 32, 22–29. [Google Scholar] [CrossRef]
  19. Pederson, R.L.; Fellows, I.M.; Ung, T.A.; Ishihara, H.; Hajela, S.P. Applications of olefin cross metathesis to commercial products. Adv. Synth. Catal. 2002, 344, 728–735. [Google Scholar] [CrossRef]
  20. Kirschning, A.; Harmrolfs, K.; Mennecke, K.; Messinger, J.; Schön, U.; Grela, K. Homo- and heterogeneous Ru-based metathesis catalysts in cross-metathesis of 15-allylestrone—Towards 17β-hydroxysteroid dehydrogenase type 1 inhibitors. Tetrahedron Lett. 2008, 49, 3019–3022. [Google Scholar] [CrossRef]
  21. Bieniek, M.; Kołoda, D.; Grela, K. A highly selective synthesis of dialkenyl sulfones via cross-metathesis of divinyl sulfone. Org. Lett. 2006, 8, 5689–5692. [Google Scholar] [CrossRef] [PubMed]
  22. Feher, F.J.; Soulivong, D.; Eklund, A.G.; Wyndham, K.D. Cross-metathesis of alkenes with vinyl-substituted silsesquioxanes and spherosilicates: A new method for synthesizing highly-functionalized Si/O frameworks. Chem. Commun. 1997, 1185–1186. [Google Scholar] [CrossRef]
  23. Itami, Y.; Marciniec, B.; Kubicki, M. Functionalization of octavinylsilsesquioxane by ruthenium-catalyzed silylative coupling versus cross-metathesis. Chemistry – A Eur. J. 2004, 10, 1239–1248. [Google Scholar] [CrossRef] [PubMed]
  24. Rogalski, S.; Pietraszuk, C.; Marciniec, B. Synthesis of siloxy-modified second generation Hoveyda-Grubbs catalysts and their catalytic activity. J. Organomet. Chem. 2009, 694, 3918–3922. [Google Scholar] [CrossRef]
  25. Żak, P.; Pietraszuk, C.; Marciniec, B.; Spólnik, G.; Danikiewicz, W. Efficient functionalisation of cubic monovinylsilsesquioxanes via cross-metathesis and silylative coupling with olefins in the presence of ruthenium complexes. Adv. Synth. Catal. 2009, 351, 2675–2682. [Google Scholar] [CrossRef]
  26. Vautravers, N.R.; Andre, P.; Slawin, A.M.Z.; Cole-Hamilton, D.J. Synthesis and characterization of photoluminescent vinylbiphenyl decorated polyhedral oligomeric silsesquioxanes. Org. Biomol. Chem. 2009, 7, 717–724. [Google Scholar] [CrossRef] [PubMed]
  27. Vautravers, N.R.; Andre, P.; Cole-Hamilton, D.J. Fluorescence activation of a polyhedral oligomeric silsesquioxane in the presence of reducing agents. J. Mater. Chem. 2009, 19, 4545–4550. [Google Scholar] [CrossRef]
  28. Bieniek, M.; Michrowska, A.; Usanov, D.L.; Grela, K. In an attempt to provide a user’s guide to the galaxy of benzylidene, alkoxybenzylidene, and indenylidene ruthenium olefin metathesis catalysts. Chem. Eur. J. 2008, 14, 806–818. [Google Scholar] [CrossRef] [PubMed]
  29. Dinger, M.B.; Mol, J.C. High turnover numbers with ruthenium-based metathesis catalysts. Adv. Synth. Catal. 2002, 344, 671–677. [Google Scholar] [CrossRef]
  30. Michael, G.; Soley, K.; Wilson, T.; Christina, O.; Joachim, R. Development of commercially viable thermomorphic catalysts for controlled free radical polymerization. In Catalysis of organic reactions, 1st ed.; Prunier, M.L., Ed.; CRC Press: Boca Raton, FL, USA, 2008; pp. 319–328. [Google Scholar]
  31. Borré, E.; Caijo, F.; Crévisy, C.; Mauduit, M. New library of aminosulfonyl-tagged Hoveyda–Grubbs type complexes: Synthesis, kinetic studies and activity in olefin metathesis transformations. Beilstein J. Org. Chem. 2010, 6, 1159–1166. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  32. Bieniek, M.; Bujok, R.; Cabaj, M.; Lugan, N.; Lavigne, G.; Arlt, D.; Grela, K. Advanced fine-tuning of Grubbs/Hoveyda olefin metathesis catalysts:  A further step toward an optimum balance between antinomic properties. J. Am. Chem. Soc. 2006, 128, 13652–13653. [Google Scholar] [CrossRef] [PubMed]
  33. Bieniek, M.; Samojłowicz, C.; Sashuk, V.; Bujok, R.; Śledź, P.; Lugan, N.l.; Lavigne, G.; Arlt, D.; Grela, K. Rational design and evaluation of upgraded Grubbs/Hoveyda olefin metathesis catalysts: Polyfunctional benzylidene ethers on the test bench. Organometallics 2011, 30, 4144–4158. [Google Scholar] [CrossRef]
  34. Luan, X.J.; Mariz, R.; Gatti, M.; Costabile, C.; Poater, A.; Cavallo, L.; Linden, A.; Dorta, R. Identification and characterization of a new family of catalytically highly active imidazolin-2-ylidenes. J. Am. Chem. Soc. 2008, 130, 6848–6858. [Google Scholar] [CrossRef] [PubMed]
  35. Vieille-Petit, L.; Luan, X.; Gatti, M.; Blumentritt, S.; Linden, A.; Clavier, H.; Nolan, S.P.; Dorta, R. Improving grubbs’ II type ruthenium catalysts by appropriately modifying the N-heterocyclic carbene ligand. Chem. Commun. 2009, 3783–3785. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  36. Gatti, M.; Vieille-Petit, L.; Luan, X.; Mariz, R.; Drinkel, E.; Linden, A.; Dorta, R. Impact of NHC ligand conformation and solvent concentration on the ruthenium-catalyzed ring-closing metathesis reaction. J. Am. Chem. Soc. 2009, 131, 9498–9499. [Google Scholar] [CrossRef] [PubMed]
  37. Vieille-Petit, L.; Clavier, H.; Linden, A.; Blumentritt, S.; Nolan, S.P.; Dorta, R. Ruthenium olefin metathesis catalysts with N-heterocyclic carbene ligands bearing n-naphthyl side chains. Organometallics 2010, 29, 775–788. [Google Scholar] [CrossRef]
  38. Samojlowicz, C.; Bieniek, M.; Zarecki, A.; Kadyrov, R.; Grela, K. The doping effect of fluorinated aromatic hydrocarbon solvents on the performance of common olefin metathesis catalysts: Application in the preparation of biologically active compounds. Chem. Commun. 2008, 6282–6284. [Google Scholar] [CrossRef] [PubMed]
Sample Availability: Not available.
Molecules 23 01722 g001 550
Figure 1. The general features of polyhedral oligomeric silsesquioxanes (POSS).
Figure 1. The general features of polyhedral oligomeric silsesquioxanes (POSS).
Molecules 23 01722 g001
Molecules 23 01722 g002 550
Figure 2. Commonly used types of ruthenium catalysts for olefin metathesis.
Figure 2. Commonly used types of ruthenium catalysts for olefin metathesis.
Molecules 23 01722 g002
Molecules 23 01722 g003 550
Figure 3. Additional ruthenium complexes used in this study.
Figure 3. Additional ruthenium complexes used in this study.
Molecules 23 01722 g003
Molecules 23 01722 g004 550
Figure 4. Family of ruthenium complexes bearing N-Heterocyclic Carbene (NHC) ligand with naphthyl side chains used in this study.
Figure 4. Family of ruthenium complexes bearing N-Heterocyclic Carbene (NHC) ligand with naphthyl side chains used in this study.
Molecules 23 01722 g004
Molecules 23 01722 sch001 550
Scheme 1. Cross metathesis of allyl-POSS 1 with the derivative of estrone 10.
Scheme 1. Cross metathesis of allyl-POSS 1 with the derivative of estrone 10.
Molecules 23 01722 sch001
Table
Table 1. Cross metathesis of allyl-polyhedral oligomeric silsesquioxanes (POSS) derivative with model partners.
Table 1. Cross metathesis of allyl-polyhedral oligomeric silsesquioxanes (POSS) derivative with model partners.
Molecules 23 01722 i001
EntryCatalystTime (h)Yield of 4 (%)Yield of 5 (%)
1[Ru]-15633
2[Ru]-25540
3Gr-II57180
4[Ru]-352831
5[Ru]-457983
6Hov-II59998
7Hov-II28073
8[Ru]-559969
9[Ru]-654057
10Ind-II500
11[Ru]-755052
12[Ru]-8500
13Nitro249064
14Nitro58776
15[Ru]-959489
16[Ru]-928169
17[Ru]-1059966
18[Ru]-1027226
19[Ru]-1155677
20[Ru]-1259182
21[Ru]-1229390
22[Ru]-1359182
23[Ru]-1459195
24[Ru]-1428780
25[Ru]-1558583
26[Ru]-1658186
27[Ru]-1759682
28[Ru]-1859082
Reaction conditions: 1 (0.5 mmol), 2 (1 mmol), or 3 (1.5 mmol), [Ru] 0.5 mol%, dichloromethane (DCM) (4 mL), room temperature (RT).
Table
Table 2. Cross metathesis of allyl-POSS 1 with derivative of androsterone 6.
Table 2. Cross metathesis of allyl-POSS 1 with derivative of androsterone 6.
Molecules 23 01722 i002
Catalyst (mol%)SolventTemperature (°C)Time (h)Yield of 7 (%)
Hov-II (0.5)DCMRT53
Hov-II (2)DCM45536
Hov-II (2)Toluene100569
Nitro (2)Toluene100572
Table
Table 3. Cross metathesis of allyl-POSS 1 with derivative of pregnenolone 8.
Table 3. Cross metathesis of allyl-POSS 1 with derivative of pregnenolone 8.
Molecules 23 01722 i003
Catalyst (mol%)SolventTemperature (°C)Time (h)Yield of 9 (%)
Hov-II (0.5)DCMRT529
Hov-II (2)Toluene100536
Nitro (2)Toluene1001046
Nitro (2)DCM452469

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Czaban-Jóźwiak, J.; Woźniak, Ł.; Ulikowski, A.; Kwiecińska, K.; Rajkiewicz, A.A.; Grela, K. Modification of Polyhedral Oligomeric Silsesquioxanes (POSS) Molecules by Ruthenium Catalyzed Cross Metathesis. Molecules 2018, 23, 1722. https://doi.org/10.3390/molecules23071722

AMA Style

Czaban-Jóźwiak J, Woźniak Ł, Ulikowski A, Kwiecińska K, Rajkiewicz AA, Grela K. Modification of Polyhedral Oligomeric Silsesquioxanes (POSS) Molecules by Ruthenium Catalyzed Cross Metathesis. Molecules. 2018; 23(7):1722. https://doi.org/10.3390/molecules23071722

Chicago/Turabian Style

Czaban-Jóźwiak, Justyna, Łukasz Woźniak, Artur Ulikowski, Katarzyna Kwiecińska, Adam A. Rajkiewicz, and Karol Grela. 2018. "Modification of Polyhedral Oligomeric Silsesquioxanes (POSS) Molecules by Ruthenium Catalyzed Cross Metathesis" Molecules 23, no. 7: 1722. https://doi.org/10.3390/molecules23071722

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