New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa
AbstractIn this study, 19 octadecanoid derivatives—four pairs of enantiomers (1–8), two racemic/scalemic mixtures (9–10), and nine biosynthetically related analogues—were obtained from the ethanolic extract of a Chinese medicinal plant, Plantago depressa Willd. Their structures were elucidated on the basis of detailed spectroscopic analyses, with the absolute configurations of the new compounds assigned by time-dependent density functional theory (TD-DFT)-based electronic circular dichroism (ECD) calculations. Six of them (1, 3–6, and 9) were reported for the first time, while 2, 7, and 8 have been previously described as derivatives and are currently obtained as natural products. Our bioassays have established that selective compounds show in vitro anti-inflammatory activity by inhibiting lipopolysaccharide-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 1696 KB)
Share & Cite This Article
Song, X.-Q.; Zhu, K.; Yu, J.-H.; Zhang, Q.; Zhang, Y.; He, F.; Cheng, Z.-Q.; Jiang, C.-S.; Bao, J.; Zhang, H. New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa. Molecules 2018, 23, 1723.
Song X-Q, Zhu K, Yu J-H, Zhang Q, Zhang Y, He F, Cheng Z-Q, Jiang C-S, Bao J, Zhang H. New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa. Molecules. 2018; 23(7):1723.Chicago/Turabian Style
Song, Xiu-Qing; Zhu, Kongkai; Yu, Jin-Hai; Zhang, Qianqian; Zhang, Yuying; He, Fei; Cheng, Zhi-Qiang; Jiang, Cheng-Shi; Bao, Jie; Zhang, Hua. 2018. "New Octadecanoid Enantiomers from the Whole Plants of Plantago depressa." Molecules 23, no. 7: 1723.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.