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Molecules 2018, 23(7), 1648; https://doi.org/10.3390/molecules23071648

Ag2O on ZrO2 as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives

School of Chemistry & Physics, University of KwaZulu-Natal, Westville Campus, Chiltern Hills, Durban 4000, South Africa
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Received: 22 May 2018 / Revised: 2 July 2018 / Accepted: 3 July 2018 / Published: 5 July 2018
(This article belongs to the Special Issue Recyclable and Re-useable Catalysts)
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Abstract

We describe the synthesis of silver loaded on zirconia and its use as an efficient catalyst for a one-pot three-component reaction to synthesize 11 indenopyrimidine derivatives, of which 7 are new compounds. The procedure involves substituted benzaldehydes, indane-1,3-dione, and guanidinium hydrochloride, with ethanol as solvent. The proposed green protocol at room temperature is simple and efficient, giving excellent yields (90–96%) in short reaction times (<30 min). The protocol works well according to the green chemistry principles with respect to high atom economy, no need for column separation, and reusability of the catalyst, which are attractive features. XRD, TEM, SEM, and BET analysis were used to characterize the catalyst materials. View Full-Text
Keywords: indenopyrimidines; no column chromatography; Ag2O/ZrO2; heterogeneous catalysis; mixed oxides; green chemistry indenopyrimidines; no column chromatography; Ag2O/ZrO2; heterogeneous catalysis; mixed oxides; green chemistry
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Bhaskaruni, S.V.H.S.; Maddila, S.; van Zyl, W.E.; Jonnalagadda, S.B. Ag2O on ZrO2 as a Recyclable Catalyst for Multicomponent Synthesis of Indenopyrimidine Derivatives. Molecules 2018, 23, 1648.

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