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Open AccessReview

Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives

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Laboratory for Inorganic Chemical Biology, Chimie ParisTech, PSL University, F-75005 Paris, France
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Laboratory for Bioorganic Chemistry of Nucleic Acids, Department of Structural Biology and Chemistry, Institute Pasteur, CNRS UMR3523, 28, rue du Docteur Roux, 75724 Paris CEDEX 15, France
*
Authors to whom correspondence should be addressed.
Molecules 2018, 23(7), 1515; https://doi.org/10.3390/molecules23071515
Received: 1 June 2018 / Revised: 19 June 2018 / Accepted: 20 June 2018 / Published: 22 June 2018
Oligonucleotides are biopolymers that can be easily modified at various locations. Thereby, the attachment of metal complexes to nucleic acid derivatives has emerged as a common pathway to improve the understanding of biological processes or to steer oligonucleotides towards novel applications such as electron transfer or the construction of nanomaterials. Among the different metal complexes coupled to oligonucleotides, ruthenium complexes, have been extensively studied due to their remarkable properties. The resulting DNA-ruthenium bioconjugates have already demonstrated their potency in numerous applications. Consequently, this review focuses on the recent synthetic methods developed for the preparation of ruthenium complexes covalently linked to oligonucleotides. In addition, the usefulness of such conjugates will be highlighted and their applications from nanotechnologies to therapeutic purposes will be discussed. View Full-Text
Keywords: ruthenium complexes; oligonucleotides; therapeutic applications; electron transfer; DNA nanomaterials ruthenium complexes; oligonucleotides; therapeutic applications; electron transfer; DNA nanomaterials
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Flamme, M.; Clarke, E.; Gasser, G.; Hollenstein, M. Applications of Ruthenium Complexes Covalently Linked to Nucleic Acid Derivatives. Molecules 2018, 23, 1515.

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