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Open AccessArticle

Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus

Osaka University of Pharmaceutical Sciences, 4-20-1, Nasahara, Takatsuki, Osaka 569-1094, Japan
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Academic Editor: Isabel C. F. R. Ferreira
Molecules 2018, 23(6), 1336; https://doi.org/10.3390/molecules23061336
Received: 15 May 2018 / Revised: 29 May 2018 / Accepted: 30 May 2018 / Published: 1 June 2018
(This article belongs to the Collection Bioactive Compounds)
Sterepinic acids A–C (13), new carboxylic acids with two primary alcohols, have been isolated from a fungal strain of Stereum sp. OUPS-124D-1 attached to the marine alga Undaria pinnatifida. Dihydro-1,5-secovibralactone (4), a new vibralactone derivative, was isolated from the same fungal metabolites together with known vibralactone A (5), and 1,5-secovibralactone (6). The planar structures of these compounds have been elucidated by spectroscopic analyses using IR, HRFABMS, and NMR spectra. To determine the absolute configuration of the compounds, we used the phenylglycine methyl ester (PGME) method. These compounds exhibited less activity in the cytotoxicity assay against cancer cell lines. View Full-Text
Keywords: sterepinic acids; Stereum sp.; marine microorganism; Undaria pinnatifida; vibralactones; phenylglycine methyl ester method sterepinic acids; Stereum sp.; marine microorganism; Undaria pinnatifida; vibralactones; phenylglycine methyl ester method
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Yamada, T.; Matsuda, M.; Seki, M.; Hirose, M.; Kikuchi, T. Sterepinic Acids A–C, New Carboxylic Acids Produced by a Marine Alga-Derived Fungus. Molecules 2018, 23, 1336.

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