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Open AccessArticle

Effects of UV-B Radiation on the Content of Bioactive Components and the Antioxidant Activity of Prunella vulgaris L. Spica during Development

by Yuhang Chen 1,2,3,4,†, Xuerong Zhang 2,†, Qiaosheng Guo 2,*, Li Liu 2, Chen Li 3,4, Liping Cao 3,4, Qin Qin 3,4, Miao Zhao 3,4 and Wenming Wang 1,*
1
Rice Research Institute, Sichuan Agricultural University, Chengdu 611130, China
2
Institute of Chinese Medicinal Materials, Nanjing Agricultural University, Nanjing 210095, China
3
College of Pharmaceutical Sciences, Chengdu Medical College, Chengdu 610500, China
4
Key Laboratory of Small Molecule Special Structure Drugs, Sichuan Institution of Higher Education/Chengdu Medical College, Chengdu 610500, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(5), 989; https://doi.org/10.3390/molecules23050989
Received: 1 March 2018 / Revised: 21 March 2018 / Accepted: 5 April 2018 / Published: 24 April 2018
The effects of UV-B radiation on the content of bioactive components and the antioxidant activity of Prunella vulgaris L. spica during development were studied. The experimental design involved two levels of UV-B radiation intensity (0 and 120 μW cm−2 nm−1). The results showed that the contents of total flavonoids, rosmarinic acid, caffeic acid and hyperoside, as well as the antioxidant capacities (DPPH and ABTS•+ scavenging activities), in the spicas significantly decreased during spica development. The content of salviaflaside in the spicas significantly increased during development. The highest contents of total flavonoids, rosmarinic acid, and caffeic acid and the highest antioxidant activities were found in spicas in the full-flowering stage, while the highest content of hyperoside was found in spicas in the bud stage. In addition, the highest content of salviaflaside was found in spicas in the mature-fruiting stage. UV-B radiation significantly promoted the synthesis of secondary metabolites, increased the contents of the main bioactive components in the three developmental stages of isolated dried spicas, and significantly increased the DPPH and ABTS•+ scavenging activities of P. vulgaris spicas in the mature-fruiting stage. Moreover, the total flavonoids content was positively correlated with the DPPH and ABTS•+ scavenging activities, and the correlation with the DPPH scavenging activity was very strong. This result shows that the highest contents of the main bioactive components in the spicas were not all found in the same developmental stages of P. vulgaris. Our research revealed that the best stage for harvesting P. vulgaris spica was between the bud stage and the full-flowering stage since harvesting at this point provides a higher content of bioactive components and a higher antioxidant capacity, which is relevant for medicinal applications. View Full-Text
Keywords: Prunella vulgaris L.; UV-B; bioactive components; antioxidant activity Prunella vulgaris L.; UV-B; bioactive components; antioxidant activity
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MDPI and ACS Style

Chen, Y.; Zhang, X.; Guo, Q.; Liu, L.; Li, C.; Cao, L.; Qin, Q.; Zhao, M.; Wang, W. Effects of UV-B Radiation on the Content of Bioactive Components and the Antioxidant Activity of Prunella vulgaris L. Spica during Development. Molecules 2018, 23, 989.

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