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Open AccessReview

Characterization of Cyclodextrin/Volatile Inclusion Complexes: A Review

Bioactive Molecules Research Laboratory, Doctoral School of Sciences and Technologies, Faculty of Sciences II, Lebanese University, Fanar, Lebanon
Unité de Chimie Environnementale et Interactions sur le Vivant (UCEIV), EA 4492, SFR Condorcet FR CNRS 3417, Université du Littoral-Côte d’Opale (ULCO), 59140 Dunkerque, France
Author to whom correspondence should be addressed.
Academic Editor: Bernard Martel
Molecules 2018, 23(5), 1204;
Received: 30 April 2018 / Revised: 13 May 2018 / Accepted: 15 May 2018 / Published: 17 May 2018
(This article belongs to the Special Issue Cyclodextrin Chemistry 2018)
Cyclodextrins (CDs) are a family of cyclic oligosaccharides that constitute one of the most widely used molecular hosts in supramolecular chemistry. Encapsulation in the hydrophobic cavity of CDs positively affects the physical and chemical characteristics of the guests upon the formation of inclusion complexes. Such a property is interestingly employed to retain volatile guests and reduce their volatility. Within this scope, the starting crucial point for a suitable and careful characterization of an inclusion complex is to assess the value of the formation constant (Kf), also called stability or binding constant. This task requires the application of the appropriate analytical method and technique. Thus, the aim of the present paper is to give a general overview of the main analytical tools used for the determination of Kf values for CD/volatile inclusion complexes. This review emphasizes on the advantages, inconvenients and limits of each applied method. A special attention is also dedicated to the improvement of the current methods and to the development of new techniques. Further, the applicability of each technique is illustrated by a summary of data obtained from the literature. View Full-Text
Keywords: cyclodextrin; fluorescence; formation constant; HPLC; ITC; NMR; phase solubility; SH-GC; TOC; UV-Visible; volatiles cyclodextrin; fluorescence; formation constant; HPLC; ITC; NMR; phase solubility; SH-GC; TOC; UV-Visible; volatiles
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MDPI and ACS Style

Kfoury, M.; Landy, D.; Fourmentin, S. Characterization of Cyclodextrin/Volatile Inclusion Complexes: A Review. Molecules 2018, 23, 1204.

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