Next Article in Journal
Antioxidant and Cytoprotective Effects of Kukoamines A and B: Comparison and Positional Isomeric Effect
Previous Article in Journal
Evaluation of Manganese Chloride’s Effect on Biosynthetic Properties of In Vitro Cultures of Eschscholzia californica Cham.
Article Menu
Issue 4 (April) cover image

Export Article

Open AccessArticle
Molecules 2018, 23(4), 972; https://doi.org/10.3390/molecules23040972

The Effects of Chinese Herbal Medicines on the Quorum Sensing-Regulated Virulence in Pseudomonas aeruginosa PAO1

1
Division of Genetics and Molecular Biology, ISB, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
2
Vice Chancellor Office, Jiangsu University, Zhenjiang 212013, China
3
Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
*
Authors to whom correspondence should be addressed.
Received: 28 December 2017 / Revised: 12 April 2018 / Accepted: 13 April 2018 / Published: 21 April 2018
(This article belongs to the Section Medicinal Chemistry)
Full-Text   |   PDF [14761 KB, uploaded 3 May 2018]   |  

Abstract

The quorum sensing (QS) system has been used by many opportunistic pathogenic bacteria to coordinate their virulence determinants in relation to cell-population density. As antibiotic-resistant bacteria are on the rise, interference with QS has been regarded as a novel way to control bacterial infections. As such, many plant-based natural products have been widely explored for their therapeutic roles. These natural products may contain anti-QS compounds that could block QS signals generation or transmission to combat QS pathogens. In this study, we report the anti-QS activities of four different Chinese herbal plant extracts: Poria cum Radix pini, Angelica dahurica, Rhizoma cibotii and Schizonepeta tenuifolia, on Pseudomonas aeruginosa PAO1. All the plants extracted using hexane, chloroform and methanol were tested and found to impair swarming motility and pyocyanin production in P. aeruginosa PAO1, particularly by Poria cum Radix pini. In addition, all the plant extracts also inhibited violacein production in C. violaceum CV026 up to 50% while bioluminescence activities were reduced in lux-based E. coli biosensors, pSB401 and pSB1075, up to about 57%. These anti-QS properties of the four medicinal plants are the first documentation that demonstrates a potential approach to attenuate pathogens’ virulence determinants. View Full-Text
Keywords: quorum sensing; natural products; Pseudomonas aeruginosa PAO1; Poria cum Radix pini; Angelica dahurica; Rhizoma cibotii; Schizonepeta tenuifolia quorum sensing; natural products; Pseudomonas aeruginosa PAO1; Poria cum Radix pini; Angelica dahurica; Rhizoma cibotii; Schizonepeta tenuifolia
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Chong, Y.M.; How, K.Y.; Yin, W.F.; Chan, K.G. The Effects of Chinese Herbal Medicines on the Quorum Sensing-Regulated Virulence in Pseudomonas aeruginosa PAO1. Molecules 2018, 23, 972.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top