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Molecules 2018, 23(4), 910;

Stryphnodendron Species Known as “Barbatimão”: A Comprehensive Report

Department of Drugs and Medicines, School of Pharmaceutical Sciences, Sao Paulo State University-UNESP, Rodovia Araraquara-Jaú, km 1, Araraquara 14800-903, Sao Paulo, Brazil
Pró Reitoria de Pesquisa e Pós-graduação, Universidade do Sagrado Coração, Bauru 17011-160, São Paulo, Brazil
Author to whom correspondence should be addressed.
Received: 1 December 2017 / Revised: 26 January 2018 / Accepted: 31 January 2018 / Published: 15 April 2018
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Stryphnodendron spp., popularly known as “barbatimão”, is the native Brazilian tree most often employed to treat wounds and infections. The aim of the present study was to highlight the importance of S. adstringens, as well as other Stryphnodendron species recognized as “barbatimão”, to human health, depicting the relevance of ethnopharmacological knowledge to scientific evidence for uses, related chemical compounds, development of pharmaceutical formulations, and the establishment of toxicity parameters. For this purpose, the literature databases PubMed, Scielo, Lilacs, CAPES Thesis and Google Scholar were searched until 2017. It was observed that stem bark was the primary part of the plant used, mainly as a decoction, for wound healing and treatment of infectious and inflammatory disorders. Confirmed biological activities, including wound healing, anti-inflammatory, antioxidant, and antimicrobial activities, were related to the presence of compounds from tannin class, mostly proanthocyanidins. Toxicity parameters for stem bark were inconclusive, but toxicity was observed to a significant extent when seeds were ingested by cattle or other animals. Due to these important and confirmed biological activities, government policy encourages the phytotherapic use of S. adstringens, and some formulations with stem bark extracts were developed and patented. Furthermore, antiprotozoal, hypoglycemic and antiviral activities were identified as promising. View Full-Text
Keywords: ethnopharmacology; medicinal plant; biological activity; tannin; catechin; wound healing ethnopharmacology; medicinal plant; biological activity; tannin; catechin; wound healing

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Souza-Moreira, T.M.; Queiroz-Fernandes, G.M.; Pietro, R.C.L.R. Stryphnodendron Species Known as “Barbatimão”: A Comprehensive Report. Molecules 2018, 23, 910.

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