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β-Glucans: Multi-Functional Modulator of Wound Healing

Institute of Molecular Biology, Slovak Academy of Sciences, Dubravska Cesta 21, 845 51 Bratislava, Slovakia
Department of Paediatrics, Jessenius Faculty of Medicine, Comenius University in Bratislava, Kollarova 2, 036 59 Martin, Slovakia
Author to whom correspondence should be addressed.
Academic Editor: Quan-Bin Han
Molecules 2018, 23(4), 806;
Received: 20 March 2018 / Revised: 29 March 2018 / Accepted: 30 March 2018 / Published: 1 April 2018
(This article belongs to the Special Issue Advances in Natural Polysaccharides Research)
PDF [3161 KB, uploaded 3 May 2018]


β-glucans are derived from a variety of sources including yeast, grain and fungus and belong to the class of drugs known as biological response modifiers. They possess a broad spectrum of biological activities that enhance immunity in humans. One promising area for β-glucans’ application is dermatology, including wound care. Topical applications of β-glucans are increasing, especially due to their pluripotent properties. Macrophages, keratinocytes and fibroblasts are considered the main target cells of β-glucans during wound healing. β-glucans enhance wound repair by increasing the infiltration of macrophages, which stimulates tissue granulation, collagen deposition and reepithelialization. β-glucan wound dressings represent a suitable wound healing agent, with great stability and resistance to wound proteases. This review summarizes the current knowledge and progress made on characterizing β-glucans’ wound healing properties in vitro and in vivo and their safety and efficacy in managing non-healing wounds or other chronic dermatological conditions and diseases. View Full-Text
Keywords: polysaccharide; natural product; immunomodulator; wound repair polysaccharide; natural product; immunomodulator; wound repair

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Majtan, J.; Jesenak, M. β-Glucans: Multi-Functional Modulator of Wound Healing. Molecules 2018, 23, 806.

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