Melatonin and Cancer Hallmarks
Department of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman 11931-166, Jordan
Molecules 2018, 23(3), 518; https://doi.org/10.3390/molecules23030518
Received: 19 January 2018 / Revised: 9 February 2018 / Accepted: 19 February 2018 / Published: 26 February 2018
(This article belongs to the Special Issue Melatonin as an Antioxidant and a Functionally Pleiotropic Molecule: Synthesis, Metabolism and Activities in Organisms)
Melatonin is a natural indoleamine produced by the pineal gland that has many functions, including regulation of the circadian rhythm. Many studies have reported the anticancer effect of melatonin against a myriad of cancer types. Cancer hallmarks include sustained proliferation, evading growth suppressors, metastasis, replicative immortality, angiogenesis, resisting cell death, altered cellular energetics, and immune evasion. Melatonin anticancer activity is mediated by interfering with various cancer hallmarks. This review summarizes the anticancer role of melatonin in each cancer hallmark. The studies discussed in this review should serve as a solid foundation for researchers and physicians to support basic and clinical studies on melatonin as a promising anticancer agent.
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Keywords:
melatonin; cancer hallmarks; anticancer; angiogenesis; metastasis; immune evasion
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Talib, W.H. Melatonin and Cancer Hallmarks. Molecules 2018, 23, 518.
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