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Molecules 2018, 23(2), 461;

A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts

Department of Chemistry “G. Ciamician”, University of Bologna, 40126 Bologna, Italy
Department of Pharmacy, University “G. D’Annunzio” of Chieti-Pescara, 66100 Chieti, Italy
Interuniversity Consortium of Structural and Systems Biology, 00136 Rome, Italy
Department of Biology, Selcuk University, Campus, 42250, 42130 Konya, Turkey
Department of Health Sciences, University of Mauritius, Réduit 80837, Mauritius
Author to whom correspondence should be addressed.
Received: 16 January 2018 / Revised: 16 February 2018 / Accepted: 17 February 2018 / Published: 19 February 2018
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The present study aims to highlight the therapeutic potential of Asphodeline lutea (AL), a wild edible plant of the Mediterranean diet. Roots, aerial parts, and flowers of AL at two different phenological stages were collected from three locations in Italy. The inhibitory activities of extracts on strategic enzymes linked to human diseases were assessed. The antioxidant properties were evaluated in vitro, using six standard bioassays. The phenolic and anthraquinone profiles were also established using HPLC-PDA. Zinc, cadmium, lead, and copper contents were also determined. All the samples inhibited acetylcholinesterase (from 1.51 to 2.20 mg GALAEs/g extract), tyrosinase (from 7.50 to 25.3 mg KAEs/g extract), and α-amylase (from 0.37 to 0.51 mmol ACAEs/g extract). Aloe-emodin and physcion were present in all parts, while rhein was not detected. The phenolic profile and the heavy metals composition of specimens gathered from three different regions of Italy were different. It can be argued that samples collected near the street can contain higher concentrations of heavy metals. The experimental data confirm that the A. lutea species could be considered as a potential source of bioactive metabolites, and its consumption could play a positive and safe role in human health maintenance. View Full-Text
Keywords: Asphodeline lutea; HPLC-PDA; heavy metals; tyrosinase; diabetes; neurodegenerative disease Asphodeline lutea; HPLC-PDA; heavy metals; tyrosinase; diabetes; neurodegenerative disease
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Melucci, D.; Locatelli, M.; Locatelli, C.; Zappi, A.; De Laurentiis, F.; Carradori, S.; Campestre, C.; Leporini, L.; Zengin, G.; Picot, C.M.N.; Menghini, L.; Mahomoodally, M.F. A Comparative Assessment of Biological Effects and Chemical Profile of Italian Asphodeline lutea Extracts. Molecules 2018, 23, 461.

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