Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity
AbstractBackground: Despite the progress achieved by anti-retroviral drug research in the last decades, the discovery of novel compounds endowed with selective antiviral activity and reduced side effects is still a necessity. At present, the most urgent requirement includes the improvement of HIV (Human Immunodeficiency Virus) prevention and sexual transmission and the development of new drugs to treat the chronic lifelong infection. Methods: Six chloro-1,4-dimethyl-9H-carbazoles (2a,b–4a,b) have been prepared following opportunely modified known chemical procedures and tested in luciferase and Escherichia coli β-galactosidase expressing CD4+, CXCR4+, CCR5+ TZM-bl cells. Results and Conclusion: a preliminary biological investigation on the synthesized small series of chloro-1,4-dimethyl-9H-carbazoles has been carried out. Among all tested compounds, a nitro-derivative (3b) showed the most interesting profile representing a suitable lead for the development of novel anti-HIV drugs. View Full-Text
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Saturnino, C.; Grande, F.; Aquaro, S.; Caruso, A.; Iacopetta, D.; Bonomo, M.G.; Longo, P.; Schols, D.; Sinicropi, M.S. Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity. Molecules 2018, 23, 286.
Saturnino C, Grande F, Aquaro S, Caruso A, Iacopetta D, Bonomo MG, Longo P, Schols D, Sinicropi MS. Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity. Molecules. 2018; 23(2):286.Chicago/Turabian Style
Saturnino, Carmela; Grande, Fedora; Aquaro, Stefano; Caruso, Anna; Iacopetta, Domenico; Bonomo, Maria G.; Longo, Pasquale; Schols, Dominique; Sinicropi, Maria S. 2018. "Chloro-1,4-dimethyl-9H-carbazole Derivatives Displaying Anti-HIV Activity." Molecules 23, no. 2: 286.
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