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Molecules
Volume 23
Issue 2
10.3390/molecules23020193
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Article

Genome-Wide Identification and Comparative Analysis of the 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Gossypium

by
Wei Liu
1,†,
Zhiqiang Zhang
1,†,
Wei Li
2,†,
Wei Zhu
1,
Zhongying Ren
2,
Zhenyu Wang
2,
Lingli Li
1,
Lin Jia
1,
Shuijin Zhu
3,* and
Zongbin Ma
1,*
1
Collaborative Innovation Center of Henan Grain Crops/Agronomy College, Henan Agricultural University, Zhengzhou 450002, China
2
State Key Laboratory of Cotton Biology/Institute of Cotton Research of Chinese Academy of Agricultural Sciences, Anyang 455000, China
3
Department of Agronomy, Zhejiang University, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Molecules 2018, 23(2), 193; https://doi.org/10.3390/molecules23020193
Received: 13 December 2017 / Revised: 19 January 2018 / Accepted: 21 January 2018 / Published: 24 January 2018
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Abstract

Terpenes are the largest and most diverse class of secondary metabolites in plants and play a very important role in plant adaptation to environment. 3-Hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is a rate-limiting enzyme in the process of terpene biosynthesis in the cytosol. Previous study found the HMGR genes underwent gene expansion in Gossypium raimondii, but the characteristics and evolution of the HMGR gene family in Gossypium genus are unclear. In this study, genome-wide identification and comparative study of HMGR gene family were carried out in three Gossypium species with genome sequences, i.e., G. raimondii, Gossypium arboreum, and Gossypium hirsutum. In total, nine, nine and 18 HMGR genes were identified in G. raimondii, G. arboreum, and G. hirsutum, respectively. The results indicated that the HMGR genes underwent gene expansion and a unique gene cluster containing four HMGR genes was found in all the three Gossypium species. The phylogenetic analysis suggested that the expansion of HMGR genes had occurred in their common ancestor. There was a pseudogene that had a 10-bp deletion resulting in a frameshift mutation and could not be translated into functional proteins in G. arboreum and the A-subgenome of G. hirsutum. The expression profiles of the two pseudogenes showed that they had tissue-specific expression. Additionally, the expression pattern of the pseudogene in the A-subgenome of G. hirsutum was similar to its paralogous gene in the D-subgenome of G. hirsutum. Our results provide useful information for understanding cytosolic terpene biosynthesis in Gossypium species. View Full-Text
Keywords: Gossypium; HMGR; terpene biosynthesis; gene expansion; pseudogene Gossypium; HMGR; terpene biosynthesis; gene expansion; pseudogene
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MDPI and ACS Style

Liu, W.; Zhang, Z.; Li, W.; Zhu, W.; Ren, Z.; Wang, Z.; Li, L.; Jia, L.; Zhu, S.; Ma, Z. Genome-Wide Identification and Comparative Analysis of the 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Gossypium. Molecules 2018, 23, 193. https://doi.org/10.3390/molecules23020193

AMA Style

Liu W, Zhang Z, Li W, Zhu W, Ren Z, Wang Z, Li L, Jia L, Zhu S, Ma Z. Genome-Wide Identification and Comparative Analysis of the 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Gossypium. Molecules. 2018; 23(2):193. https://doi.org/10.3390/molecules23020193

Chicago/Turabian Style

Liu, Wei, Zhiqiang Zhang, Wei Li, Wei Zhu, Zhongying Ren, Zhenyu Wang, Lingli Li, Lin Jia, Shuijin Zhu, and Zongbin Ma. 2018. "Genome-Wide Identification and Comparative Analysis of the 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase (HMGR) Gene Family in Gossypium" Molecules 23, no. 2: 193. https://doi.org/10.3390/molecules23020193

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