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Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases

IRCCS Centro Neurolesi “Bonino-Pulejo”, Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy
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Molecules 2018, 23(12), 3305; https://doi.org/10.3390/molecules23123305
Received: 16 November 2018 / Revised: 7 December 2018 / Accepted: 10 December 2018 / Published: 13 December 2018
N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet. NAC is a glutathione precursor and shows antioxidant and anti-inflammatory activities. In addition to the uses quoted in the literature, NAC may be considered helpful in therapies to counteract neurodegenerative and mental health diseases. Furthermore, this compound has been evaluated for its neuroprotective potential in the prevention of cognitive aging dementia. NAC is inexpensive, commercially available and no relevant side effects were observed after its administration. The purpose of this paper is to give an overview on the effects and applications of NAC in Parkinson’s and Alzheimer’s disorders and in neuropathic pain and stroke. View Full-Text
Keywords: N-acetylcysteine; glutathione precursor; oxidative stress; Parkinson’s disease; Alzheimer’s disease; neuropathic pain; stroke N-acetylcysteine; glutathione precursor; oxidative stress; Parkinson’s disease; Alzheimer’s disease; neuropathic pain; stroke
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Tardiolo, G.; Bramanti, P.; Mazzon, E. Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases. Molecules 2018, 23, 3305.

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