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Recent Studies on Cyclic 1,7-Diarylheptanoids: Their Isolation, Structures, Biological Activities, and Chemical Synthesis

1
College of Pharmacy, Yeungnam University, Gyeongsan 38541, Korea
2
Advanced Bio Convergence Center, Pohang Technopark Foundation, Pohang 37668, Korea
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(12), 3107; https://doi.org/10.3390/molecules23123107
Received: 11 October 2018 / Revised: 16 November 2018 / Accepted: 22 November 2018 / Published: 27 November 2018
Diarylheptanoids are a family of plant secondary metabolites with a 7 carbon skeleton possessing two phenyl rings at the 1- and 7-positions. They can be subdivided into acyclic and cyclic diarylheptanoids where the latter are further divided into meta,meta-bridged biphenyls ([7.0]metacyclophanes) and meta,para-bridged diphenyl ether heptanoids (oxa[7.1]metapara-cyclophanes). Since the isolation of curcumin from the rhizomes of turmeric (Curcuma longa) in 1815 which was named curcumin, a variety of diarylheptanoids have been isolated from a number of plant families such as Aceraceae, Actinidiaceae, Betulaceae, Burseraceae, Casuarinaceae, Juglandaceae, Leguminosae, Myricaceae, and Zingiberaceae. Earlier studies on these diarylheptanoids have been summarized on several occasions, of which the main themes only focus on isolation, structure elucidation, and the biological properties of linear types. Only a few have covered cyclic diarylheptanoids and their chemical synthesis has been covered lastly by Zhu et al. in 2000. The present paper has, therefore, covered recent progress in cyclic diarylheptanoids focusing on the isolation, structural and biological features, and chemical synthesis. View Full-Text
Keywords: diarylheptanoid; biphenyl heptanoid; diphenyl ether heptanoid; total synthesis diarylheptanoid; biphenyl heptanoid; diphenyl ether heptanoid; total synthesis
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Jahng, Y.; Park, J.G. Recent Studies on Cyclic 1,7-Diarylheptanoids: Their Isolation, Structures, Biological Activities, and Chemical Synthesis. Molecules 2018, 23, 3107.

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