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Open AccessFeature PaperReview

Enantioselective Drug Recognition by Drug Transporters

School of Pharmacy, Aichi Gakuin University, Nagoya 464-8650, Japan
Academic Editor: Maria Elizabeth Tiritan
Molecules 2018, 23(12), 3062;
Received: 25 October 2018 / Revised: 21 November 2018 / Accepted: 22 November 2018 / Published: 22 November 2018
Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton-coupled folate transporters (PCFT/SLC46A1), organic anion transporting polypeptides (OATPs/SLCO), organic anion transporters (OATs/SLC22), organic cation transporters (OCTs/SLC22), and multidrug and toxin extrusions (MATEs/SLC47) have been isolated, and their functions have been elucidated. Enantioselectivity has been demonstrated in the pharmacokinetics and efficacy of drugs, and is important for elucidating the relationship with recognition of drugs by drug transporters from a chiral aspect. Enantioselectivity in the transport of drugs by drug transporters and the inhibitory effects of drugs on drug transporters has been summarized in this review. View Full-Text
Keywords: drug transporter; enantioselectivity; transport; inhibition; pharmacokinetics drug transporter; enantioselectivity; transport; inhibition; pharmacokinetics
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Uwai, Y. Enantioselective Drug Recognition by Drug Transporters. Molecules 2018, 23, 3062.

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