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Molecules 2018, 23(11), 2901;

Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization

Department of Chemical and Materials Engineering, Chang Gung University, Taoyuan 33302, Taiwan
Department of Urology, Chang Gung Memorial Hospital, Linkou, Taoyuan 33302, Taiwan
Academic Editors: Maria Elizabeth Tiritan, Madalena Pinto and Carla Sofia Garcia Fernandes
Received: 8 October 2018 / Revised: 4 November 2018 / Accepted: 5 November 2018 / Published: 7 November 2018
PDF [1044 KB, uploaded 7 November 2018]


Stripping crystallization (SC) is introduced in this work for chiral purification of R-phenylglycinol from the enantiomer mixture with an initial concentration ranging from 0.90 to 0.97. As opposed to the solid–liquid transformation in melt crystallization, the three-phase transformation occurs in SC at low pressures during the cooling process. SC combines melt crystallization and vaporization to produce a crystalline product and mixture vapor from a mixture melt due to the three-phase transformation. Thermodynamic calculations were applied to determine the operating pressure for the three-phase transformation during the cooling process in the SC experiments. To consider the possible deviations between the calculated and the actual three-phase transformation conditions, the product purity and the recovery ratio of R-phenylglycinol were investigated within a range of operating pressures during the cooling process. View Full-Text
Keywords: crystallization; vaporization; purification; phenylglycinol crystallization; vaporization; purification; phenylglycinol

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Shiau, L.-D. Chiral Separation of the Phenylglycinol Enantiomers by Stripping Crystallization. Molecules 2018, 23, 2901.

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