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Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, I-87036 Rende, Italy
Department of Pharmacy-Drug Science, University of Bari “Aldo Moro”, I-70125 Bari, Italy
Institute of Sciences of Food Production, National Research Council (ISPA-CNR), 70126 Bari, Italy
Author to whom correspondence should be addressed.
Molecules 2018, 23(11), 2829;
Received: 11 October 2018 / Revised: 24 October 2018 / Accepted: 29 October 2018 / Published: 31 October 2018
(This article belongs to the Special Issue Natural Bioactives in Anti-Obesity Therapy)
PDF [474 KB, uploaded 31 October 2018]


Pancreatic lipase, a key enzyme for lipid absorption, is one of the most important targets for the treatment of obesity, while natural compounds have recently attracted much interest as potential inhibitors of this enzyme. Here, in an attempt to find new effective agents, the methanolic extract from Moricandia arvensis (L.) DC. and its sub-extracts were investigated for their potential inhibitory activity. The ability to inhibit pancreatic lipase was verified through the in vitro evaluation of the prevention of p-nitrophenyl caprylate hydrolysis. The antioxidant activity was also verified by means of DPPH and β-carotene bleaching tests. Compositional profiling revealed that flavonoid glycosides were the main specialized metabolites present in the methanolic extract from the aerial parts of the plant with kaempferol and quercetin representing the two O-glycosylated aglycones. Kaempferol-3-O-β-(2″-O-glucosyl)-rutinoside and kaempferol-3-O-a-arabinosyl-7-O-rhamnoside were the most abundant flavonols. The crude methanolic extract and the dichloromethane and ethyl acetate sub-extracts showed a strong lipase inhibitory activity, with IC50 values of 2.06 ± 0.02, 1.52 ± 0.02 and 1.31 ± 0.02 mg/mL, respectively. The best capacity to scavenge DPPH radical was detected for the ethyl acetate sub-extract (IC50 = 171.9 ± 1.0 µg/mL), which was also effective in protecting linoleic acid from peroxidation (IC50 = 35.69 ± 2.30 µg/mL). Obtained results support the hypothesis that M. arvensis can be a source of bioactive phytochemicals for the pharmacological inhibition of dietary lipids absorption. View Full-Text
Keywords: antioxidant; flavonoids; glucosinolates; obesity; pancreatic lipase antioxidant; flavonoids; glucosinolates; obesity; pancreatic lipase

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Marrelli, M.; Morrone, F.; Argentieri, M.P.; Gambacorta, L.; Conforti, F.; Avato, P. Phytochemical and Biological Profile of Moricandia arvensis (L.) DC.: An Inhibitor of Pancreatic Lipase. Molecules 2018, 23, 2829.

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