Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs
by
Roopa Thapar
Roopa Thapar
Department of Molecular and Cellular Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA
Academic Editor: Junji Iwahara
Molecules 2018, 23(11), 2789; https://doi.org/10.3390/molecules23112789
Received: 28 September 2018 / Revised: 25 October 2018 / Accepted: 26 October 2018 / Published: 27 October 2018
(This article belongs to the Special Issue Protein-DNA Interactions: From Biophysics to Genomics)
DNA double-strand breaks (DSBs) are deleterious lesions that are generated in response to ionizing radiation or replication fork collapse that can lead to genomic instability and cancer. Eukaryotes have evolved two major pathways, namely homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DSBs. Whereas the roles of protein-DNA interactions in HR and NHEJ have been fairly well defined, the functions of small and long non-coding RNAs and RNA-DNA hybrids in the DNA damage response is just beginning to be elucidated. This review summarizes recent discoveries on the identification of non-coding RNAs and RNA-mediated regulation of DSB repair.
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Keywords:
DNA repair; long non-coding RNA; microRNA; DNA damage; double-strand breaks; NHEJ; HR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Thapar, R. Regulation of DNA Double-Strand Break Repair by Non-Coding RNAs. Molecules 2018, 23, 2789.
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