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Open AccessArticle

Binding of Red Clover Isoflavones to Actin as A Potential Mechanism of Anti-Metastatic Activity Restricting the Migration of Cancer Cells

1
Institute of Food Technology and Analysis, Faculty of Biotechnology and Food Sciences, Lodz University of Technology, 90-924 Lodz, Poland
2
Bioinformatics and High-Performance Computing Research Group (BIO-HPC), Computer Engineering Department, Universidad Católica de Murcia (UCAM), Guadalupe, 30107 Murcia, Spain
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(10), 2471; https://doi.org/10.3390/molecules23102471
Received: 11 August 2018 / Revised: 18 September 2018 / Accepted: 25 September 2018 / Published: 26 September 2018
(This article belongs to the Collection Bioactive Compounds)
Actin functions are crucial for the ability of the cell to execute dynamic cytoskeleton reorganization and movement. Nutraceuticals that form complexes with actin and reduce its polymerization can be used in cancer therapy to prevent cell migration and metastasis of tumors. The aim of this study was to evaluate the ability of isoflavones to form complexes with actin. Docking simulation and isothermal titration calorimetry were used for this purpose. The formation of complexes by hydrogen bonds, hydrophobic and π-π interactions was demonstrated. Interactions occurred at the ATP binding site, which may limit the rotation of the actin molecule observed during polymerization and also at the site responsible for contacts during polymerization, reducing the ability of the molecule to form filaments. The greatest therapeutic potential was demonstrated by isoflavones occurring in red clover sprouts, i.e., biochanin A and formononetin, being methoxy derivatives of genistein and daidzein. View Full-Text
Keywords: actin; cell migration; isoflavones; anti-metastatic activity actin; cell migration; isoflavones; anti-metastatic activity
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MDPI and ACS Style

Budryn, G.; Grzelczyk, J.; Pérez-Sánchez, H. Binding of Red Clover Isoflavones to Actin as A Potential Mechanism of Anti-Metastatic Activity Restricting the Migration of Cancer Cells. Molecules 2018, 23, 2471. https://doi.org/10.3390/molecules23102471

AMA Style

Budryn G, Grzelczyk J, Pérez-Sánchez H. Binding of Red Clover Isoflavones to Actin as A Potential Mechanism of Anti-Metastatic Activity Restricting the Migration of Cancer Cells. Molecules. 2018; 23(10):2471. https://doi.org/10.3390/molecules23102471

Chicago/Turabian Style

Budryn, Grażyna; Grzelczyk, Joanna; Pérez-Sánchez, Horacio. 2018. "Binding of Red Clover Isoflavones to Actin as A Potential Mechanism of Anti-Metastatic Activity Restricting the Migration of Cancer Cells" Molecules 23, no. 10: 2471. https://doi.org/10.3390/molecules23102471

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