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Open AccessArticle

Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives

1
School of Pharmacy, Lanzhou University, Lanzhou 730000, China
2
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China
3
Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571010, China
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(10), 2422; https://doi.org/10.3390/molecules23102422
Received: 2 September 2018 / Revised: 14 September 2018 / Accepted: 19 September 2018 / Published: 21 September 2018
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Abstract

In an attempt to find the neonicotinoid insecticides, twenty novel dihydropyridine derivatives were designed, “green” synthesized via one pot facile three-component reaction and evaluated for their bioactivities against Tetranychus cinnabarinus, Myzus persicae, Brevicoryne brassicae, Fusarium oxysporum f. sp. vasinfectum, Magnaporthe oryzae, Sclerotinia sclerotiorum and Botrytis cinereal. All of the tested compounds showed potent insecticidal activity, and some were much better in comparison with imidacloprid (IMI). Especially, compounds 3d (LC50: 0.011 mM) and 5c (LC50: 0.025 mM) were 12.2- and 5.4-fold more active than IMI (LC50: 0.135 mM) against T. cinnabarinus, respectively. Moreover, out of all the derivatives, compound 3d (LC50: 0.0015 mM) exhibited the strongest insecticidal activity against B. brassicae and compound 3i (LC50: 0.0007 mM) displayed the strongest insecticidal activity against M. persicae. Surprisingly, when the concentration of compound 4 was 50 mg/L, the inhibition rate against F. oxysporum and S. sclerotiorum reached 45.00% and 65.83%, respectively. The present work indicated that novel dihydropyridine derivatives could be used as potential lead compounds for developing neonicotinoid insecticides and agricultural fungicides. View Full-Text
Keywords: neonicotinoid; insecticide; fungicide; dihydropyridine derivatives; three-component reaction neonicotinoid; insecticide; fungicide; dihydropyridine derivatives; three-component reaction
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yang, G.-Z.; Shang, X.-F.; Cheng, P.-L.; Yin, X.-D.; Zhu, J.-K.; Liu, Y.-Q.; Zhang, J.; Zhang, Z.-J. Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives. Molecules 2018, 23, 2422.

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