Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives
AbstractIn an attempt to find the neonicotinoid insecticides, twenty novel dihydropyridine derivatives were designed, “green” synthesized via one pot facile three-component reaction and evaluated for their bioactivities against Tetranychus cinnabarinus, Myzus persicae, Brevicoryne brassicae, Fusarium oxysporum f. sp. vasinfectum, Magnaporthe oryzae, Sclerotinia sclerotiorum and Botrytis cinereal. All of the tested compounds showed potent insecticidal activity, and some were much better in comparison with imidacloprid (IMI). Especially, compounds 3d (LC50: 0.011 mM) and 5c (LC50: 0.025 mM) were 12.2- and 5.4-fold more active than IMI (LC50: 0.135 mM) against T. cinnabarinus, respectively. Moreover, out of all the derivatives, compound 3d (LC50: 0.0015 mM) exhibited the strongest insecticidal activity against B. brassicae and compound 3i (LC50: 0.0007 mM) displayed the strongest insecticidal activity against M. persicae. Surprisingly, when the concentration of compound 4 was 50 mg/L, the inhibition rate against F. oxysporum and S. sclerotiorum reached 45.00% and 65.83%, respectively. The present work indicated that novel dihydropyridine derivatives could be used as potential lead compounds for developing neonicotinoid insecticides and agricultural fungicides. View Full-Text
- Supplementary File 1:
PDF-Document (PDF, 1642 KB)
Share & Cite This Article
Yang, G.-Z.; Shang, X.-F.; Cheng, P.-L.; Yin, X.-D.; Zhu, J.-K.; Liu, Y.-Q.; Zhang, J.; Zhang, Z.-J. Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives. Molecules 2018, 23, 2422.
Yang G-Z, Shang X-F, Cheng P-L, Yin X-D, Zhu J-K, Liu Y-Q, Zhang J, Zhang Z-J. Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives. Molecules. 2018; 23(10):2422.Chicago/Turabian Style
Yang, Guan-Zhou; Shang, Xiao-Fei; Cheng, Pi-Le; Yin, Xiao-Dan; Zhu, Jia-Kai; Liu, Ying-Qian; Zhang, Jing; Zhang, Zhi-Jun. 2018. "Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives." Molecules 23, no. 10: 2422.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.