Next Article in Journal
Structural, Luminescent and Thermal Properties of Heteronuclear PdII–LnIII–PdII Complexes of Hexadentate N2O4 Schiff Base Ligand
Previous Article in Journal
Avocado Seed: A Comparative Study of Antioxidant Content and Capacity in Protecting Oil Models from Oxidation
Open AccessArticle

Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives

School of Pharmacy, Lanzhou University, Lanzhou 730000, China
Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730000, China
Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571010, China
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2018, 23(10), 2422;
Received: 2 September 2018 / Revised: 14 September 2018 / Accepted: 19 September 2018 / Published: 21 September 2018
PDF [639 KB, uploaded 21 September 2018]


In an attempt to find the neonicotinoid insecticides, twenty novel dihydropyridine derivatives were designed, “green” synthesized via one pot facile three-component reaction and evaluated for their bioactivities against Tetranychus cinnabarinus, Myzus persicae, Brevicoryne brassicae, Fusarium oxysporum f. sp. vasinfectum, Magnaporthe oryzae, Sclerotinia sclerotiorum and Botrytis cinereal. All of the tested compounds showed potent insecticidal activity, and some were much better in comparison with imidacloprid (IMI). Especially, compounds 3d (LC50: 0.011 mM) and 5c (LC50: 0.025 mM) were 12.2- and 5.4-fold more active than IMI (LC50: 0.135 mM) against T. cinnabarinus, respectively. Moreover, out of all the derivatives, compound 3d (LC50: 0.0015 mM) exhibited the strongest insecticidal activity against B. brassicae and compound 3i (LC50: 0.0007 mM) displayed the strongest insecticidal activity against M. persicae. Surprisingly, when the concentration of compound 4 was 50 mg/L, the inhibition rate against F. oxysporum and S. sclerotiorum reached 45.00% and 65.83%, respectively. The present work indicated that novel dihydropyridine derivatives could be used as potential lead compounds for developing neonicotinoid insecticides and agricultural fungicides. View Full-Text
Keywords: neonicotinoid; insecticide; fungicide; dihydropyridine derivatives; three-component reaction neonicotinoid; insecticide; fungicide; dihydropyridine derivatives; three-component reaction

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material


Share & Cite This Article

MDPI and ACS Style

Yang, G.-Z.; Shang, X.-F.; Cheng, P.-L.; Yin, X.-D.; Zhu, J.-K.; Liu, Y.-Q.; Zhang, J.; Zhang, Z.-J. Facile Three-Component Synthesis, Insecticidal and Antifungal Evaluation of Novel Dihydropyridine Derivatives. Molecules 2018, 23, 2422.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top