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Molecules 2018, 23(1), 50;

A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing

Department of Dermatology, University of California–Davis, Sacramento, CA 95816, USA
Drexel University College of Medicine, Philadelphia, PA 19129, USA
Emory University School of Medicine, Atlanta, GA 30307, USA
Department of Biological Sciences, California State University–Sacramento, Sacramento, CA 95819, USA
Veterans Administration, Northern California Health Care System, Department of Dermatology, Mather, CA 95655, USA
Author to whom correspondence should be addressed.
Received: 11 December 2017 / Revised: 22 December 2017 / Accepted: 24 December 2017 / Published: 26 December 2017
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Catecholamines play an important regulatory role in cutaneous wound healing. The exact role of dopamine in human epidermis has yet to be fully elucidated. Current published evidence describes its differential effects on two separate families of G protein coupled receptors: D1-like and D2-like dopamine receptors. Dopamine may enhance angiogenesis and wound healing through its action on dopamine D1 receptors, while impairing wound healing when activating D2 receptors. This review summarizes the evidence for the role of dopamine in wound healing and describes potential mechanisms behind its action on D1 versus D2-like receptors in the skin. View Full-Text
Keywords: wounds; dopamine; wound healing wounds; dopamine; wound healing

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Vaughn, A.R.; Davis, M.J.; Sivamani, R.K.; Isseroff, R.R. A Concise Review of the Conflicting Roles of Dopamine-1 versus Dopamine-2 Receptors in Wound Healing. Molecules 2018, 23, 50.

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