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Open AccessArticle

Prognostic Significance of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Association with Promoter Methylation of the ALCAM Gene in Breast Cancer

1
Department of Surgery, School of Medicine, Catholic University of Daegu, Daegu 42471, Korea
2
Department of Pathology, School of Medicine, Catholic University of Daegu, Daegu 42471, Korea
*
Author to whom correspondence should be addressed.
Molecules 2018, 23(1), 131; https://doi.org/10.3390/molecules23010131
Received: 28 November 2017 / Revised: 24 December 2017 / Accepted: 7 January 2018 / Published: 9 January 2018
(This article belongs to the Special Issue Modulators of Histone Methylation: A Medicinal Chemistry Perspective)
Activated leukocyte cell adhesion molecule (ALCAM) has been implicated in tumorigenesis. In this study, we studied DNA methylation status of the ALCAM gene using pyrosequencing in breast cancer tissues. We analyzed the association between the methylation status of the ALCAM gene and its expression. Also, the effects of inflammation on the ALCAM gene methylation and its expression were investigated. The ALCAM gene methylation was associated with the ALCAM transcripts in tumor tissues. The methylation status of the ALCAM gene was not significantly different between tumor and normal tissues. The level of ALCAM transcripts was associated with the expression of TNFα, NF-κB p50, IL-4, and intratumoral inflammation. The IHC expression of ALCAM was associated with histologic grade, HER2 overexpression and molecular subtype. The expression of TNFα, NF-κB p50, and IL-4 showed significant association with the clinicopathologic characteristics. In conclusion, the ALCAM gene methylation was related to the level of ALCAM transcripts. Also, the level of ALCAM transcripts was associated with the inflammatory markers in breast cancer. Our results suggest that the methylation of the ALCAM gene contributes to the decreased expression of ALCAM. Also, ALCAM is linked to the inflammatory response in breast cancer. View Full-Text
Keywords: activated leukocyte cell adhesion molecule; methylation; inflammation; epigenetics; breast cancer activated leukocyte cell adhesion molecule; methylation; inflammation; epigenetics; breast cancer
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MDPI and ACS Style

Jeong, Y.J.; Oh, H.K.; Park, S.H.; Bong, J.G. Prognostic Significance of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Association with Promoter Methylation of the ALCAM Gene in Breast Cancer. Molecules 2018, 23, 131. https://doi.org/10.3390/molecules23010131

AMA Style

Jeong YJ, Oh HK, Park SH, Bong JG. Prognostic Significance of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Association with Promoter Methylation of the ALCAM Gene in Breast Cancer. Molecules. 2018; 23(1):131. https://doi.org/10.3390/molecules23010131

Chicago/Turabian Style

Jeong, Young J.; Oh, Hoon K.; Park, Sung H.; Bong, Jin G. 2018. "Prognostic Significance of Activated Leukocyte Cell Adhesion Molecule (ALCAM) in Association with Promoter Methylation of the ALCAM Gene in Breast Cancer" Molecules 23, no. 1: 131. https://doi.org/10.3390/molecules23010131

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