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Article

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

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Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya
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Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI)—Walter Reed Project, Kisumu and Nairobi, P.O. Box 54-40100, Kisumu, Kenya
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State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.O. Box 999078, China
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Department of Chemistry and Molecular Biology, University of Gothenburg, SE-40530 Gothenburg, Sweden
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Swedish NMR Centre, University of Gothenburg, P.O. Box 465, SE-40530 Gothenburg, Sweden
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Authors to whom correspondence should be addressed.
Molecules 2017, 22(9), 1514; https://doi.org/10.3390/molecules22091514
Received: 28 July 2017 / Revised: 28 August 2017 / Accepted: 6 September 2017 / Published: 10 September 2017
Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (511), were isolated from the CH2Cl2/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC50 1.7 ± 0.1 μM, with relatively low cytotoxicity, IC50 > 21 μM, against four cell-lines. View Full-Text
Keywords: Tephrosia purpurea subsp. leptostachya; stem; flavone; antiplasmodial; cytotoxicity Tephrosia purpurea subsp. leptostachya; stem; flavone; antiplasmodial; cytotoxicity
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MDPI and ACS Style

Atilaw, Y.; Muiva-Mutisya, L.; Ndakala, A.; Akala, H.M.; Yeda, R.; Wu, Y.J.; Coghi, P.; Wong, V.K.W.; Erdélyi, M.; Yenesew, A. Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya. Molecules 2017, 22, 1514. https://doi.org/10.3390/molecules22091514

AMA Style

Atilaw Y, Muiva-Mutisya L, Ndakala A, Akala HM, Yeda R, Wu YJ, Coghi P, Wong VKW, Erdélyi M, Yenesew A. Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya. Molecules. 2017; 22(9):1514. https://doi.org/10.3390/molecules22091514

Chicago/Turabian Style

Atilaw, Yoseph, Lois Muiva-Mutisya, Albert Ndakala, Hoseah M. Akala, Redemptah Yeda, Yu J. Wu, Paolo Coghi, Vincent K.W. Wong, Máté Erdélyi, and Abiy Yenesew. 2017. "Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya" Molecules 22, no. 9: 1514. https://doi.org/10.3390/molecules22091514

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