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Molecules 2017, 22(9), 1514;

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya
Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI)—Walter Reed Project, Kisumu and Nairobi, P.O. Box 54-40100, Kisumu, Kenya
State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.O. Box 999078, China
Department of Chemistry and Molecular Biology, University of Gothenburg, SE-40530 Gothenburg, Sweden
Swedish NMR Centre, University of Gothenburg, P.O. Box 465, SE-40530 Gothenburg, Sweden
Authors to whom correspondence should be addressed.
Received: 28 July 2017 / Revised: 28 August 2017 / Accepted: 6 September 2017 / Published: 10 September 2017
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Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (511), were isolated from the CH2Cl2/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC50 1.7 ± 0.1 μM, with relatively low cytotoxicity, IC50 > 21 μM, against four cell-lines. View Full-Text
Keywords: Tephrosia purpurea subsp. leptostachya; stem; flavone; antiplasmodial; cytotoxicity Tephrosia purpurea subsp. leptostachya; stem; flavone; antiplasmodial; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Atilaw, Y.; Muiva-Mutisya, L.; Ndakala, A.; Akala, H.M.; Yeda, R.; Wu, Y.J.; Coghi, P.; Wong, V.K.W.; Erdélyi, M.; Yenesew, A. Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya. Molecules 2017, 22, 1514.

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