Next Article in Journal
Unique Roles of Gold Nanoparticles in Drug Delivery, Targeting and Imaging Applications
Next Article in Special Issue
Forbidden Coherence Transfer of 19F Nuclei to Quantitatively Measure the Dynamics of a CF3-Containing Ligand in Receptor-Bound States
Previous Article in Journal
Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2
Previous Article in Special Issue
Interactions Controlling the Slow Dynamic Conformational Motions of Ubiquitin
Review

Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 151-742, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2017, 22(9), 1447; https://doi.org/10.3390/molecules22091447
Received: 31 July 2017 / Accepted: 27 August 2017 / Published: 31 August 2017
(This article belongs to the Special Issue Recent Advances in Biomolecular NMR Spectroscopy)
Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis, which triggers severe pulmonary diseases. Recently, multidrug/extensively drug-resistant tuberculosis strains have emerged and continue to threaten global health. Because of the development of drug-resistant tuberculosis, there is an urgent need for novel antibiotics to treat these drug-resistant bacteria. In light of the clinical importance of M. tuberculosis, 2067 structures of M. tuberculsosis proteins have been determined. Among them, 52 structures have been solved and studied using solution nuclear magnetic resonance (NMR). The functional details based on structural analysis of M. tuberculosis using NMR can provide essential biochemical data for the development of novel antibiotic drugs. In this review, we introduce diverse structural and biochemical studies on M. tuberculosis proteins determined using NMR spectroscopy. View Full-Text
Keywords: Mycobacterium tuberculosis; antibiotic target; nuclear magnetic resonance (NMR); biomolecular interaction Mycobacterium tuberculosis; antibiotic target; nuclear magnetic resonance (NMR); biomolecular interaction
Show Figures

Figure 1

MDPI and ACS Style

Kim, D.-H.; Kang, S.-M.; Lee, B.-J. Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery. Molecules 2017, 22, 1447. https://doi.org/10.3390/molecules22091447

AMA Style

Kim D-H, Kang S-M, Lee B-J. Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery. Molecules. 2017; 22(9):1447. https://doi.org/10.3390/molecules22091447

Chicago/Turabian Style

Kim, Do-Hee; Kang, Sung-Min; Lee, Bong-Jin. 2017. "Solution NMR Studies of Mycobacterium tuberculosis Proteins for Antibiotic Target Discovery" Molecules 22, no. 9: 1447. https://doi.org/10.3390/molecules22091447

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop