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Molecules 2017, 22(7), 1167;

Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents

Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Korea
The authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Zhenjun Yang
Received: 17 June 2017 / Revised: 8 July 2017 / Accepted: 10 July 2017 / Published: 12 July 2017
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A series of acyclic selenopurine nucleosides 3af and 4ag were synthesized based on the bioisosteric rationale between oxygen and selenium, and then evaluated for antiviral activity. Among the compounds tested, seleno-acyclovir (4a) exhibited the most potent anti-herpes simplex virus (HSV)-1 (EC50 = 1.47 µM) and HSV-2 (EC50 = 6.34 µM) activities without cytotoxicity up to 100 µM, while 2,6-diaminopurine derivatives 4eg exhibited significant anti-human cytomegalovirus (HCMV) activity, which is slightly more potent than the guanine derivative 4d, indicating that they might act as prodrugs of seleno-ganciclovir (4d). View Full-Text
Keywords: antiviral; acyclic selenopurine nucleoside; prodrug; anti-herpetic antiviral; acyclic selenopurine nucleoside; prodrug; anti-herpetic

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Sahu, P.K.; Umme, T.; Yu, J.; Kim, G.; Qu, S.; Naik, S.D.; Jeong, L.S. Structure-Activity Relationships of Acyclic Selenopurine Nucleosides as Antiviral Agents. Molecules 2017, 22, 1167.

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