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Molecules 2017, 22(7), 1100;

Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves

Institute of Tropical Pathology and Public Health, Federal University of Goias, Goiânia 74605-050, Brazil
Unit of Exact and Technologic Sciences, Goias State University, Anápolis 75132-400, Brazil
Faculty of Pharmacy, Federal University of Goias, Goiânia 74605-170, Brazil
Chemistry Institute, Federal University of Goiás, Goiânia 74690-900, Brazil
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C. F. R. Ferreira
Received: 23 May 2017 / Accepted: 29 June 2017 / Published: 4 July 2017
(This article belongs to the Collection Bioactive Compounds)
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This work describes the isolation and structural elucidation of compounds from the leaves of Myrcia tomentosa (Aubl.) DC. (goiaba-brava) and evaluates the antimicrobial activity of the crude extract, fractions and isolated compounds against bacteria and fungi. Column chromatography was used to fractionate and purify the extract of the M. tomentosa leaves and the chemical structures of the compounds were determined using spectroscopic techniques. The antibacterial and antifungal activities were assessed using the broth microdilution method. The phytochemical investigation isolated 11 compounds: α-bisabolol, α-bisabolol oxide B, α-cadinol, β-sitosterol, n-pentacosane, n-tetracosane, quercetin, kaempferol, avicularin, juglanin and guaijaverin. The crude ethanolic extract and its fractions were tested against 15 bacteria and 9 yeasts. The crude extract inhibited the in vitro growth of yeasts at concentration of 4 to 32 μg/mL. The hexane, dichloromethane, ethyl acetate and aqueous fractions inhibited Candida sp. at concentrations of 4 to 256 μg/mL, whereas the Cryptococcus sp. isolates were inhibited only by the hexane and dichloromethane fractions in minimal inhibitory concentrations (MICs) at 16 to 64 μg/mL. The flavonoid quercetin-3-O-α-arabinofuranose (avicularin) was the most active compound, inhibiting Candida species in concentrations of 2 to 32 μg/mL. The MIC values suggest potential activity of this plant species against yeast. View Full-Text
Keywords: myrtaceae; antifungal activity; avicularin; Candida sp.; phytochemistry; flavonoid myrtaceae; antifungal activity; avicularin; Candida sp.; phytochemistry; flavonoid

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Da Silva Sa, F.A.; De Paula, J.A.M.; Dos Santos, P.A.; De Almeida Ribeiro Oliveira, L.; De Almeida Ribeiro Oliveira, G.; Liao, L.M.; De Paula, J.R.; Do Rosario Rodrigues Silva, M. Phytochemical Analysis and Antimicrobial Activity of Myrcia tomentosa (Aubl.) DC. Leaves. Molecules 2017, 22, 1100.

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