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Molecules 2017, 22(7), 1098;

Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii

Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey
Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Istanbul Yeni Yuzyil University, Istanbul 34110, Turkey
Authors to whom correspondence should be addressed.
Received: 9 June 2017 / Revised: 25 June 2017 / Accepted: 28 June 2017 / Published: 1 July 2017
(This article belongs to the Collection Bioactive Compounds)
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The dichloromethane extract of the roots of Prangos hulusii, a recently described endemic species from Turkey, has yielded nine known and one new prenylated coumarins. The structures were elucidated by spectroscopic methods and direct comparison with the reference compounds where available. The root extract and its prenylated coumarins exhibit antimicrobial activity against nine standard and six clinically isolated strains at a concentration between 5 and 125 µg/mL. In particular, the new coumarin, 4′-senecioiloxyosthol (1), displayed 5 µg/mL MIC (Minimum Inhibitory Concentration) value against Bacillus subtilis ATCC 9372, murraol (4) and auraptenol (5) showed 63 µg/mL MIC value against Klebsiella pneumoniae ATCC 4352 and Bacillus subtilis ATCC 9372, and isoimperatorin (9) exhibited 16 µg/mL MIC value. View Full-Text
Keywords: Prangos hulusii; pyrenylated coumarins; antibacterial activity Prangos hulusii; pyrenylated coumarins; antibacterial activity

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Tan, N.; Yazıcı-Tütüniş, S.; Bilgin, M.; Tan, E.; Miski, M. Antibacterial Activities of Pyrenylated Coumarins from the Roots of Prangos hulusii. Molecules 2017, 22, 1098.

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