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Molecules 2017, 22(6), 990;

Protein Interaction and Na/K-ATPase-Mediated Signal Transduction

Marshall Institute for Interdisciplinary Research, Marshall University, Huntington, WV 25703, USA
Author to whom correspondence should be addressed.
Academic Editor: Robert Kiss
Received: 7 April 2017 / Revised: 1 June 2017 / Accepted: 2 June 2017 / Published: 14 June 2017
(This article belongs to the Special Issue Cardiotonic Steroids)
Full-Text   |   PDF [1373 KB, uploaded 14 June 2017]   |  


The Na/K-ATPase (NKA), or Na pump, is a member of the P-type ATPase superfamily. In addition to pumping ions across cell membrane, it is engaged in assembly of multiple protein complexes in the plasma membrane. This assembly allows NKA to perform many non-pumping functions including signal transduction that are important for animal physiology and disease progression. This article will focus on the role of protein interaction in NKA-mediated signal transduction, and its potential utility as target for developing new therapeutics. View Full-Text
Keywords: Na/K-ATPase; Src; signal transduction; cardiotonic steroids; drug target Na/K-ATPase; Src; signal transduction; cardiotonic steroids; drug target

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Cui, X.; Xie, Z. Protein Interaction and Na/K-ATPase-Mediated Signal Transduction. Molecules 2017, 22, 990.

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