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Molecules 2017, 22(6), 900;

Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)

Center for Studies and Research of Medicinal Plants, Federal University of San Francisco Valley, 56306-385 Petrolina-PE, Brazil
Departament of Physiology, Federal University of Sergipe, 49100-000 Aracaju-SE, Brazil
Embrapa-Semiárido, 56302-970 Petrolina-PE, Brazil
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, 14040-903 Ribeirão Preto-SP, Brazil
Federal Institute of Education, Science and Technology Sertão Pernambucano, 56300-000 Petrolina-PE, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Olga Tzakou
Received: 18 April 2017 / Revised: 24 May 2017 / Accepted: 26 May 2017 / Published: 30 May 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
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Medicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p < 0.05). The same was observed in both phases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of KATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine. View Full-Text
Keywords: pain; medicinal plants; essential oil; terpenoids pain; medicinal plants; essential oil; terpenoids

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De Oliveira Júnior, R.G.; Ferraz, C.A.A.; Silva, J.C.; De Oliveira, A.P.; Diniz, T.C.; E Silva, M.G.; Quintans Júnior, L.J.; De Souza, A.V.V.; Dos Santos, U.S.; Turatti, I.C.C.; Lopes, N.P.; Lorenzo, V.P.; Almeida, J.R.G.S. Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae). Molecules 2017, 22, 900.

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