Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)
AbstractMedicinal plants have been widely used in the treatment of chronic pain. In this study, we describe the antinociceptive effect of the essential oil from Croton conduplicatus (the EO 25, 50, and 100 mg/kg, i.p.), a medicinal plant native to Brazil. Antinociceptive activity was investigated by measuring the nociception induced by acetic acid, formalin, hot plate and carrageenan. A docking study was performed with the major constituents of the EO (E-caryophyllene, caryophyllene oxide, and camphor). The EO reduced nociceptive behavior at all doses tested in the acetic acid-induced nociception test (p < 0.05). The same was observed in both phases (neurogenic and inflammatory) of the formalin test. When the hot-plate test was conducted, the EO (50 mg/kg) extended the latency time after 60 min of treatment. The EO also reduced leukocyte migration at all doses, suggesting that its antinociceptive effect involves both central and peripheral mechanisms. Pretreatment with glibenclamide and atropine reversed the antinociceptive effect of the EO on the formalin test, suggesting the involvement of KATP channels and muscarinic receptors. The docking study revealed a satisfactory interaction profile between the major components of the EO and the different muscarinic receptor subtypes (M2, M3, and M4). These results corroborate the medicinal use of C. conduplicatus in folk medicine. View Full-Text
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de Oliveira Júnior, R.G.; Ferraz, C.A.A.; Silva, J.C.; de Oliveira, A.P.; Diniz, T.C.; e Silva, M.G.; Quintans Júnior, L.J.; de Souza, A.V.V.; dos Santos, U.S.; Turatti, I.C.C.; Lopes, N.P.; Lorenzo, V.P.; Almeida, J.R.G.S. Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae). Molecules 2017, 22, 900.
de Oliveira Júnior RG, Ferraz CAA, Silva JC, de Oliveira AP, Diniz TC, e Silva MG, Quintans Júnior LJ, de Souza AVV, dos Santos US, Turatti ICC, Lopes NP, Lorenzo VP, Almeida JRGS. Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae). Molecules. 2017; 22(6):900.Chicago/Turabian Style
de Oliveira Júnior, Raimundo G.; Ferraz, Christiane A.A.; Silva, Juliane C.; de Oliveira, Ana P.; Diniz, Tâmara C.; e Silva, Mariana G.; Quintans Júnior, Lucindo J.; de Souza, Ana V.V.; dos Santos, Uiliane S.; Turatti, Izabel C.C.; Lopes, Norberto P.; Lorenzo, Vitor P.; Almeida, Jackson R.G.S. 2017. "Antinociceptive Effect of the Essential Oil from Croton conduplicatus Kunth (Euphorbiaceae)." Molecules 22, no. 6: 900.
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