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Molecules 2017, 22(6), 881;

Current Perspective on In Vivo Molecular Imaging of Immune Cells

Bioimaging Research Team, Korea Basic Science Institute, Cheongju 28119, Korea
Immunotherapy Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 34141, Korea
Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Korea
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editors: Patrick Gamez and Ana B. Caballero
Received: 7 April 2017 / Accepted: 19 May 2017 / Published: 26 May 2017
(This article belongs to the Special Issue Metal Based Drugs: Opportunities and Challenges)
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Contemporaneous development of improved immune cell-based therapies, and powerful imaging tools, has prompted growth in technologies for immune cell tracking in vivo. Over the past couple of decades, imaging tools such as magnetic resonance imaging (MRI) and optical imaging have successfully monitored the trafficking patterns of therapeutic immune cells and assisted the evaluation of the success or failure of immunotherapy. Recent advancements in imaging technology have made imaging an indispensable module of immune cell-based therapies. In this review, emerging applications of non-radiation imaging modalities for the tracking of a range of immune cells are discussed. Applications of MRI, NIR, and other imaging tools have demonstrated the potential of non-invasively surveying the fate of both phagocytic and non-phagocytic immune cells in vivo. View Full-Text
Keywords: cellular imaging; image-tracking; immune cells; magnetic resonance imaging; optical imaging cellular imaging; image-tracking; immune cells; magnetic resonance imaging; optical imaging

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Seth, A.; Park, H.S.; Hong, K.S. Current Perspective on In Vivo Molecular Imaging of Immune Cells. Molecules 2017, 22, 881.

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