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Towards Precision Engineering of Canonical Polyketide Synthase Domains: Recent Advances and Future Prospects

Sampling Terrestrial Environments for Bacterial Polyketides

Department of Biology, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Author to whom correspondence should be addressed.
Academic Editor: Kira J. Weissman
Molecules 2017, 22(5), 707;
Received: 28 January 2017 / Revised: 14 April 2017 / Accepted: 18 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Polyketides)
Bacterial polyketides are highly biologically active molecules that are frequently used as drugs, particularly as antibiotics and anticancer agents, thus the discovery of new polyketides is of major interest. Since the 1980s discovery of polyketides has slowed dramatically due in large part to the repeated rediscovery of known compounds. While recent scientific and technical advances have improved our ability to discover new polyketides, one key area has been under addressed, namely the distribution of polyketide-producing bacteria in the environment. Identifying environments where producing bacteria are abundant and diverse should improve our ability to discover (bioprospect) new polyketides. This review summarizes for the bioprospector the state-of-the-field in terrestrial microbial ecology. It provides insight into the scientific and technical challenges limiting the application of microbial ecology discoveries for bioprospecting and summarizes key developments in the field that will enable more effective bioprospecting. The major recent efforts by researchers to sample new environments for polyketide discovery is also reviewed and key emerging environments such as insect associated bacteria, desert soils, disease suppressive soils, and caves are highlighted. Finally strategies for taking and characterizing terrestrial samples to help maximize discovery efforts are proposed and the inclusion of non-actinomycetal bacteria in any terrestrial discovery strategy is recommended. View Full-Text
Keywords: polyketides; bioprospecting; microbial ecology polyketides; bioprospecting; microbial ecology
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MDPI and ACS Style

Hill, P.; Heberlig, G.W.; Boddy, C.N. Sampling Terrestrial Environments for Bacterial Polyketides. Molecules 2017, 22, 707.

AMA Style

Hill P, Heberlig GW, Boddy CN. Sampling Terrestrial Environments for Bacterial Polyketides. Molecules. 2017; 22(5):707.

Chicago/Turabian Style

Hill, Patrick, Graham W. Heberlig, and Christopher N. Boddy. 2017. "Sampling Terrestrial Environments for Bacterial Polyketides" Molecules 22, no. 5: 707.

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