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Open AccessReview

Oleuropein and Cancer Chemoprevention: The Link is Hot

Laboratory for Translational Oncology and Personalized Medicine, Rashid Latif Medical College, Lahore 54000, Pakistan
Department of Food and Nutrition, National Institute of Health Dr. Ricardo Jorge, I.P., Av. Padre Cruz, 1649-016 Lisbon, Portugal
Center for Study in Animal Science, Praça Gomes Teixeira, Apartado 55142, 4051-401 Porto, Portugal
Research Group on Community Nutrition and Oxidative Stress and CIBEROBN—Physiopathology of Obesity and Nutrition, University of Balearic Islands, Palma de Mallorca E-07122, Balearic Islands, Spain
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran 1435916471, Iran
Department of Pharmaceutical Botany, Iuliu Hațieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
ICHAT and Institute for Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Calea Mănăştur 3-5, 400372 Cluj-Napoca, Romania
Department of Pharmaceutical Sciences, College of Pharmacy, Larkin University, Miami, FL 33169, USA
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Molecules 2017, 22(5), 705;
Received: 6 March 2017 / Revised: 18 April 2017 / Accepted: 24 April 2017 / Published: 29 April 2017
(This article belongs to the Special Issue Cancer Chemoprevention)
Cancer comprises a collection of related diseases characterized by the existence of altered cellular pathways resulting in an abnormal tendency for uncontrolled growth. A broad spectrum, coordinated, and personalized approach focused on targeting diverse oncogenic pathways with low toxicity and economic natural compounds can provide a real benefit as a chemopreventive and/or treatment of this complex disease. Oleuropein, a bioactive phenolic compound mainly present in olive oil and other natural sources, has been reported to modulate several oncogenic signalling pathways. This review presents and critically discusses the available literature about the anticancer and onco-suppressive activity of oleuropein and the underlying molecular mechanisms implicated in the anticarcinogenic and therapeutic effects. The existence of limitations and the promising perspectives of research on this phenolic compound are also critically analyzed and discussed. View Full-Text
Keywords: cancer; chemopreventive effect; oleuropein; olive oil cancer; chemopreventive effect; oleuropein; olive oil
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Ahmad Farooqi, A.; Fayyaz, S.; Silva, A.S.; Sureda, A.; Nabavi, S.F.; Mocan, A.; Nabavi, S.M.; Bishayee, A. Oleuropein and Cancer Chemoprevention: The Link is Hot. Molecules 2017, 22, 705.

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