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Bergamot Essential Oil Attenuates Anxiety-Like Behaviour in Rats

Department of Pharmacy, Health and Nutritional Sciences, Section of Preclinical and Translational Pharmacology, University of Calabria, 87036 Rende, Italy
First Department of Pharmacology, Daiichi College of Pharmaceutical Sciences, 815-8511 Fukuoka, Japan
Department of Physiology and Anatomy, Tohoku Pharmaceutical University, 981-8558 Sendai, Japan
Department of Pharmacy-Drug Sciences, University of Bari Aldo Moro, IT-70125 Bari, Italy
Department of Health Sciences, University “Magna Graecia” of Catanzaro, 88100 Catanzaro, Italy
Author to whom correspondence should be addressed.
Academic Editor: Olga Tzakou
Molecules 2017, 22(4), 614;
Received: 15 March 2017 / Revised: 7 April 2017 / Accepted: 9 April 2017 / Published: 11 April 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
Preclinical studies have recently highlighted that bergamot essential oil (BEO) is endowed with remarkable neurobiolological effects. BEO can affect synaptic transmission, modulate electroencephalographic activity and it showed neuroprotective and analgesic properties. The phytocomplex, along with other essential oils, is also widely used in aromatherapy to minimize symptoms of stress-induced anxiety and mild mood disorders. However, only limited preclinical evidences are actually available. This study examined the anxiolytic/sedative-like effects of BEO using an open field task (OFT), an elevated plus-maze task (EPM), and a forced swimming task (FST) in rats. This study further compared behavioural effects of BEO to those of the benzodiazepine diazepam. Analysis of data suggests that BEO induces anxiolytic-like/relaxant effects in animal behavioural tasks not superimposable to those of the DZP. The present observations provide further insight to the pharmacological profile of BEO and support its rational use in aromatherapy. View Full-Text
Keywords: bergamot essential oil; diazepam; behavioural tests; rat bergamot essential oil; diazepam; behavioural tests; rat
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MDPI and ACS Style

Rombolà, L.; Tridico, L.; Scuteri, D.; Sakurada, T.; Sakurada, S.; Mizoguchi, H.; Avato, P.; Corasaniti, M.T.; Bagetta, G.; Morrone, L.A. Bergamot Essential Oil Attenuates Anxiety-Like Behaviour in Rats. Molecules 2017, 22, 614.

AMA Style

Rombolà L, Tridico L, Scuteri D, Sakurada T, Sakurada S, Mizoguchi H, Avato P, Corasaniti MT, Bagetta G, Morrone LA. Bergamot Essential Oil Attenuates Anxiety-Like Behaviour in Rats. Molecules. 2017; 22(4):614.

Chicago/Turabian Style

Rombolà, Laura, Laura Tridico, Damiana Scuteri, Tsukasa Sakurada, Shinobu Sakurada, Hirokazu Mizoguchi, Pinarosa Avato, Maria T. Corasaniti, Giacinto Bagetta, and Luigi A. Morrone 2017. "Bergamot Essential Oil Attenuates Anxiety-Like Behaviour in Rats" Molecules 22, no. 4: 614.

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