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Molecules 2017, 22(3), 460;

Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from Qinghai-Tibet Plateau

2,* , 2
College of Science, Tibet University, Lhasa 8500, Tibet, China
School of Pharmacy, Fudan University, Shanghai 201203, China
School of Life Science, Fudan University, Shanghai 200438, China
Authors to whom correspondence should be addressed.
Academic Editors: Olga Tzakou and Derek J. McPhee
Received: 26 December 2016 / Accepted: 11 March 2017 / Published: 13 March 2017
(This article belongs to the Special Issue Essential Oils: Chemistry and Bioactivity)
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Waldheimia glabra is traditionally used as incense and as an anti-influenza drug by Tibetans in China. Here, we collected W. glabra from the Gangs Rinpoche mountain at an altitude of 5200 m, and analyzed its essential oil by gas chromatography-mass spectrometry (GC-MS) combined with the retention indices (RI). Twenty-seven compounds, representing 72.4% of the total essential oil, were identified, including α-bisabolol (20.2%), valeranone (11.8%), chamazulene (9.9%), spathulenol (8.2%), β-caryophyllene (6.1%), and caryophyllene oxide (5.2%). Bioactivity evaluation of the essential oil revealed that it exhibited potent anti-influenza effect on viruses H3N2 and anti-inflammatory effect by inhibiting the lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages, but no anti-complementary activity. View Full-Text
Keywords: Waldheimia glabra; Tibetan medicine; essential oil; anti-influenza; anti-inflammatory Waldheimia glabra; Tibetan medicine; essential oil; anti-influenza; anti-inflammatory

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De, J.; Lu, Y.; Ling, L.; Peng, N.; Zhong, Y. Essential Oil Composition and Bioactivities of Waldheimia glabra (Asteraceae) from Qinghai-Tibet Plateau. Molecules 2017, 22, 460.

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