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Molecules 2017, 22(4), 604;

Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings

National Institute of Materials Physics, Atomistilor Street, No. 105 bis, P.O. Box MG 07, 077125 Magurele, Romania
Emergency Hospital Floreasca Bucharest, 8 Calea Floresca, Sector 1, 014461 Bucharest, Romania
Surgery Department, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari, Sector 5, 050474 Bucharest, Romania
HORIBA Jobin Yvon S.A.S., 6-18, rue du Canal, 91165 Longjumeau CEDEX, France
Author to whom correspondence should be addressed.
Academic Editors: Krasimir Vasilev, Alex Cavallaro and Peter Zilm
Received: 6 March 2017 / Revised: 31 March 2017 / Accepted: 7 April 2017 / Published: 9 April 2017
(This article belongs to the Special Issue Antibacterial Materials and Coatings)
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The present study is focused on the synthesis, characterization and antifungal evaluation of zinc-doped hydroxyapatite (Zn:HAp) coatings. The Zn:HAp coatings were deposited on a pure Si (Zn:HAp_Si) and Ti (Zn:HAp_Ti) substrate by a sol-gel dip coating method using a zinc-doped hydroxyapatite nanogel. The nature of the crystal phase was determined by X-ray diffraction (XRD). The crystalline phase of the prepared Zn:HAp composite was assigned to hexagonal hydroxyapatite in the P63/m space group. The colloidal properties of the resulting Zn:HAp (xZn = 0.1) nanogel were analyzed by Dynamic Light Scattering (DLS) and zeta potential. Scanning Electron Microscopy (SEM) was used to investigate the morphology of the zinc-doped hydroxyapatite (Zn:HAp) nanogel composite and Zn:HAp coatings. The elements Ca, P, O and Zn were found in the Zn:HAp composite. According to the EDX results, the degree of Zn substitution in the structure of Zn:HAp composite was 1.67 wt%. Moreover, the antifungal activity of Zn:HAp_Si and Zn:HAp_Ti against Candida albicans (C. albicans) was evaluated. A decrease in the number of surviving cells was not observed under dark conditions, whereas under daylight and UV light illumination a major decrease in the number of surviving cells was observed. View Full-Text
Keywords: zinc; hydroxyapatite; C. albicans; thin layer zinc; hydroxyapatite; C. albicans; thin layer

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Iconaru, S.L.; Prodan, A.M.; Buton, N.; Predoi, D. Structural Characterization and Antifungal Studies of Zinc-Doped Hydroxyapatite Coatings. Molecules 2017, 22, 604.

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