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Molecules 2017, 22(2), 267;

Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum

School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
Guangdong Provincial Key Laboratory of Chinese Medicine Pharmaceutics, Southern Medical University, Guangzhou 510515, China
Author to whom correspondence should be addressed.
Academic Editors: Quan-Bin Han and Jian-Xin Pu
Received: 27 December 2016 / Revised: 5 February 2017 / Accepted: 6 February 2017 / Published: 13 February 2017
(This article belongs to the Special Issue Diterpene and Its Significance in Natural Medicine)
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Cancer is one of the most common lethal diseases, and natural products have been extensively studied as anticancer agents considering their availability, low toxicity, and economic affordability. Plants belonging to the genus Aconitum have been widely used medically in many Asian countries since ancient times. These plants have been proven effective for treating several types of cancer, such as lung, stomach, and liver cancers. The main effective components of Aconitum plants are diterpenoid alkaloids—which are divided into C18-, C19-, C20-, and bis-diterpenoid alkaloids—are reportedly some of the most promising, naturally abundant compounds for treating cancer. This review focuses on the progress of diterpenoid alkaloids with different structures derived from Aconitum plants and some of their derivatives with potential anticancer activities. We hope that this work can serve as a reference for further developing Aconitum diterpenoid alkaloids as anticancer agents. View Full-Text
Keywords: anticancer; genus Aconitum; diterpenoid alkaloids anticancer; genus Aconitum; diterpenoid alkaloids

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Ren, M.-Y.; Yu, Q.-T.; Shi, C.-Y.; Luo, J.-B. Anticancer Activities of C18-, C19-, C20-, and Bis-Diterpenoid Alkaloids Derived from Genus Aconitum. Molecules 2017, 22, 267.

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